Pharmacy Practice, Clinical Pharmacy Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.
Eur Rev Med Pharmacol Sci. 2022 Apr;26(7):2373-2387. doi: 10.26355/eurrev_202204_28467.
Drug-related problems (DRPs) could affect patient care and lead to deleterious manifestations, therefore, this investigation aimed to review the recently published studies concerning DRPs to improve their availability to clinical pharmacists, hoping that this information will be supportive and relevant to their practice settings. MATERIALS AND METHODS: A search of Elsevier, Sage, Springer/Nature, and Wiley online libraries on Egyptian Knowledge Bank (EKB) was limited to the cumulative period from 1/1/2015 to 20/10/2020. The abstracts of 156 articles were critically reviewed and 50 articles were included based on relevance while excluding books. The selected articles reported DRPs and different strategies to reduce them. Moreover, drug-drug interactions (DDIs) in various patient populations were confirmed by many articles. Additionally, potential drug-drug interactions (pDDIs) predisposing factors were reported by others. RESULTS: 24 articles (48%) illustrated DDIs, 5 articles (10%) demonstrated ADRs, 4 articles (8%) showed medication errors (MEs), and 25 articles (50%) revealed efforts to reduce DRPs. The psychiatric population is at the utmost risk of pDDIs. Polypharmacy was the furthest recurrently reported risk factor related to DDIs. Adverse drug events (ADEs) increased healthcare costs. Different strategies to avoid DRPs were published through the stated period. CONCLUSIONS: Our findings can be supportive to healthcare professionals in enhancing their patients' quality of care by reducing the exposure to ADEs.
药物相关问题 (DRP) 可能会影响患者的治疗效果,并导致不良后果,因此,本研究旨在回顾最近发表的有关 DRP 的研究,以提高临床药师对其的了解,希望这些信息能够支持并适用于他们的工作环境。
在爱思唯尔、塞奇、施普林格/自然和威利在线图书馆以及埃及知识库 (EKB) 上进行了搜索,时间范围限于 2015 年 1 月 1 日至 2020 年 10 月 20 日。对 156 篇文章的摘要进行了批判性审查,并根据相关性选择了 50 篇文章,同时排除了书籍。所选文章报告了 DRP 以及减少 DRP 的不同策略。此外,许多文章证实了各种患者群体中的药物-药物相互作用 (DDI)。此外,其他人报告了潜在的药物-药物相互作用 (pDDI) 的诱发因素。
24 篇文章 (48%) 说明了 DDI,5 篇文章 (10%) 说明了不良反应 (ADR),4 篇文章 (8%) 表明了用药错误 (ME),25 篇文章 (50%) 表明了减少 DRP 的努力。精神科患者最容易发生 pDDI。药物合用是最常报道的与 DDI 相关的风险因素。药物不良事件 (ADE) 增加了医疗保健成本。在研究期间,发表了不同的策略来避免 DRP。
我们的研究结果可以支持医疗保健专业人员通过减少 ADE 的发生来提高患者的护理质量。