IRCCS Policlinico S. Orsola-Malpighi, Alma Mater Studiorum Università di Bologna, Bologna, Italy; Italian Nutraceutical Society (SINut), Bologna, Italy.
Eur Rev Med Pharmacol Sci. 2022 Apr;26(7):2443-2459. doi: 10.26355/eurrev_202204_28479.
Mood disorders affect more than 500 million people around the world. In the last decade, their prevalence has increased, and many people suffer from nervousness, anxiety, and stress at least once in their lives. The incidence of mood disorders and anxiety increases during perimenopause or under stressful conditions. The social restrictions introduced during the COVID-19 pandemic have significantly increased the normal burden of psychological and psychic disorders. In moderate to severe cases, pharmacological treatment is currently recommended, while in mild disorders, especially in the initial phase, psychological therapy is preferable. It is known that several nutrients are crucial for brain function. Among them, folate (vitamin B9), cyanocobalamin (vitamin B12), and S-adenosyl-L-methionine (SAMe) have been shown to influence various neurobiological processes. Overall, the available evidence suggests that dietary supplementation with folic acid, vitamin B12, and SAMe can be beneficial for people with mild mood disorders.
心境障碍影响着全球超过 5 亿人。在过去的十年中，它们的患病率有所增加，许多人一生中至少会经历一次紧张、焦虑和压力。围绝经期或在压力环境下，心境障碍和焦虑的发病率会增加。COVID-19 大流行期间实施的社会限制措施极大地增加了心理和精神障碍的正常负担。在中度至重度病例中，目前推荐药物治疗，而在轻度障碍中，特别是在初始阶段，心理治疗更为可取。已知有几种营养物质对大脑功能至关重要。其中，叶酸（维生素 B9）、氰钴胺素（维生素 B12）和 S-腺苷-L-甲硫氨酸（SAMe）已被证明影响各种神经生物学过程。总的来说，现有证据表明，补充叶酸、维生素 B12 和 SAMe 对轻度心境障碍患者可能有益。
