School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China.
Department of Nuclear Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230001, P. R. China.
J Org Chem. 2022 May 6;87(9):6471-6478. doi: 10.1021/acs.joc.2c00388. Epub 2022 Apr 20.
This report describes a method for the deoxyfluorination of alcohols with KF as the fluorine source via in situ generation of highly active CFSOF. Diverse functionalities, including halogen, nitro, ketone, ester, alkene, and alkyne, are well tolerated. Mild conditions, a short reaction time, and a wide substrate scope make this method an excellent choice for the construction of C-F bonds.
本报告描述了一种通过原位生成高活性 CFSOF 用 KF 作为氟源对醇进行脱氧氟化的方法。多种官能团，包括卤素、硝基、酮、酯、烯烃和炔烃，都能很好地耐受。温和的条件、短的反应时间和广泛的底物范围使得该方法成为构建 C-F 键的理想选择。
