人类免疫缺陷病毒感染的黄斑微血管分析。
Analysis of Macular Microvasculature in Human Immunodeficiency Virus Infection.
机构信息
Faculty of Medicine, Department of Ophthalmology, Cukurova University, Adana, Turkey.
Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Cukurova University, Adana, Turkey.
出版信息
Ocul Immunol Inflamm. 2023 May;31(4):728-733. doi: 10.1080/09273948.2022.2056709. Epub 2022 Apr 20.
PURPOSE
To evaluate the retinal and choroidal microvascular blood flow in patients with human immunodeficiency virus (HIV) infection using optical coherence tomography angiography (OCTA).
METHODS
Macular OCTA parameters including vessel density (VD) of parafoveal superficial capillary plexus (SCP-VD) and deep capillary plexus (DCP-VD), foveal vessel density (FD), foveal avascular zone area, and flow area of choriocapillaris were analyzed in 42 HIV-positive patients, and compared with 42 healthy controls.
RESULTS
The mean SCP-VD, DCP-VD and FD were significantly lower in HIV-positive group compared with controls (p < .001, p = .014, p = .026; respectively). Reduced SCP-VD was associated with higher HIV RNA plasma level (r = -0.400, p = .021) and lower CD4 + T cell count (r = 0.314, p = .046) in HIV-positive patients.
CONCLUSIONS
Macular microvascular blood flow is affected by HIV infection. OCTA can detect microvascular flow abnormalities in retinal capillary plexus in HIV-positive patients.
目的
利用光相干断层扫描血管造影术（OCTA）评估人类免疫缺陷病毒（HIV）感染患者的视网膜和脉络膜微血管血流。
方法
分析 42 例 HIV 阳性患者和 42 例健康对照者的黄斑 OCTA 参数，包括旁中心凹浅层毛细血管丛（SCP-VD）和深层毛细血管丛（DCP-VD）的血管密度（VD）、中心凹血管密度（FD）、中心凹无血管区面积和脉络膜毛细血管血流面积。
结果
与对照组相比，HIV 阳性组的平均 SCP-VD、DCP-VD 和 FD 显著降低（p<0.001，p=0.014，p=0.026；分别）。SCP-VD 降低与 HIV 阳性患者血浆中 HIV RNA 水平较高（r=-0.400，p=0.021）和 CD4+T 细胞计数较低（r=0.314，p=0.046）相关。
结论
HIV 感染会影响黄斑区微血管血流。OCTA 可检测 HIV 阳性患者视网膜毛细血管丛的微血管血流异常。
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