Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain.
Department of Ophthalmology, Centro Internacional de Oftalmología Avanzada, Madrid, Spain.
Clin Exp Ophthalmol. 2020 Jan;48(1):44-52. doi: 10.1111/ceo.13648. Epub 2019 Oct 16.
To provide a normative vessel density (VD) database for the macula through swept-source optical coherence tomography angiography (OCTA) and to assess the main determinants of this measurement.
In contrast with dye angiography, the recently introduced OCTA technique allows for the non-invasive measurement of retinal and choroidal VD metrics.
Cross-sectional study.
The right eyes of 346 healthy subjects were studied. In 105 subjects both eyes were imaged.
Foveal and parafoveal macular VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and in the choriocapillaris (CC) layer. Also recorded were age, sex, axial length (AL), foveal and choroidal thickness (CT).
Normative database and determinants of macular VD measured by OCTA.
Mean participant age was 38.3 ± 20.1 years (mean ± SD) (range 5-83). Foveal VDs in the different plexuses were: SCP 22.1% ± 5.0% (7.3-35.1), DCP 19.9% ± 6.3% (6.9-51.2) and CC: 52.8% ± 4.3% (40.2-62.1). Parafoveal VDs ranged from 45.4% ± 3.7% to 51.8% ± 4.6%. Positive correlation was observed between foveal VD and foveal thickness (R = .327), as well as between parafoveal DCP VD and CT (R = .250;P ≤ .006), while correlation with age was negative in the SCP and CC (R = -.283;P < .001). No associations were detected between macular VD and sex or AL (P ≥ .05).
Macular VD showed wide individual variation, was positively correlated with foveal thickness and with CT, negatively correlated with age, and showed no correlation with AL or sex.
通过扫频源光相干断层扫描血管造影术（OCTA）提供黄斑的规范血管密度（VD）数据库，并评估该测量的主要决定因素。
与染料血管造影术相反，最近引入的 OCTA 技术允许对视网膜和脉络膜 VD 指标进行非侵入性测量。
横断面研究。
研究了 346 名健康受试者的右眼。在 105 名受试者中，双眼均进行了成像。
在视网膜浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）和脉络膜毛细血管层中获得黄斑中心凹和旁中心凹的 VD 测量值。还记录了年龄、性别、眼轴长度（AL）、中心凹和脉络膜厚度（CT）。
OCTA 测量的黄斑 VD 的规范数据库和决定因素。
平均参与者年龄为 38.3±20.1 岁（平均值±标准差）（范围 5-83 岁）。不同丛中的黄斑中心凹 VD 为：SCP 22.1%±5.0%（7.3-35.1），DCP 19.9%±6.3%（6.9-51.2）和 CC：52.8%±4.3%（40.2-62.1）。旁中心凹 VD 范围为 45.4%±3.7%至 51.8%±4.6%。在黄斑中心凹，VD 与中心凹厚度呈正相关（R =.327），在旁中心凹 DCP VD 与 CT 呈正相关（R =.250；P≤.006），而在 SCP 和 CC 中，VD 与年龄呈负相关（R = -.283；P <.001）。在黄斑 VD 与性别或 AL 之间未检测到相关性（P≥.05）。
黄斑 VD 显示出广泛的个体差异，与中心凹厚度和 CT 呈正相关，与年龄呈负相关，与 AL 或性别无关。
