Correlation of Troponin I with Left Ventricular Ejection Fraction in Acute Coronary Syndrome.

Coronary artery disease is the most common cause of heart disease and the single most important cause of premature death in the world.In 2001,CVD was responsible for 29% of all deaths and 14% of the 1.5 billion lost DALYs.By 2030,when population is expected to reach 8.2 billion,33%of all deaths will be caused by CVD. Over the last decade, cardiovascular disease(CVD) has become the single largest cause of death worldwide. Myocardial necrosis causes release of structural proteins and other intracellular macromolecules into the cardiac interstitium as a consequence of compromise of the integrity of cellular membranes. On the basis of improved sensitivity and superior tissue-specificity compared with the other available biomarkers of necrosis, cardiac troponin is the preferred biomarker for the detection of myocardial injury. Material and Objectives:

• To determine the correlation between Troponin I with left ventricular ejection fraction in acute coronary syndrome.

Methodology:

• Source of data: The patients with ACS, who gave written consent for the study, in the IP departments of General Medicine.
• Study Design: Prospective observational study.
• Sample size: 75.

Methods of Collection of Data:

• The present study were conducted on patients diagnosed with ACS. Data regarding patient characteristics including age, sex, gender as well as history of chronic heart disease were collected. Patients evaluated during the hospital stay using daily ECG, troponin I, Ejection fraction of left ventricle measured using echocardiography at the 4th day of admission and catergorised as normal (>50%), mildly reduced(40-50%)and reduced(<40%) EF ced(<40%).

Observation: In this study the mean Troponin I is 8332.47 with a standard deviation of 8371.17. Minimum value is 23 and maximum value is 32000. Maximum Troponin I and Ejection Fraction has been correlated with a Pearson correlation coefficient -0.739,which concludes that Maximum troponin I and EF are highly negatively correlated with a significant p value of <0.001. Conclusion: The present study concludes that serum troponin I level has a strong negative correlation with the left ventricular ejection fraction in patients with acute coronary syndrome and hence can be used to predict the LVEF.