Mysore Medical College and Research Institute, Mysuru.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Coronary artery disease is a multifactorial disease affected by multiple factors. Dyslipidemia is one of the most important factor for atherosclerosis and its consequences. Hence the present study aims to study lipid profile pattern in patients diagnosed with acute myocardial infarction.
The present study is a cross sectional study conducted at tertiary care hospital from september 2020 to october 2021.A total of 80 patients with age more than 18years diagnosed with Acute myocardial infarction for first time were included in study after receiving informed consent.Acute myocardial infarction was diagnosed by patients history,ECG,cardiac biomarkers.Patients with hyperthyroidism and already on antilipidemics were excluded from study.
Out of 80 patients there were 62 male patients (77.5%) and 18 female patients (22.5%).66 patients were diagnosed to have STEMI(82.50%)and 14 patients had NSTEMI(17.5%). Patients with age more than 18years age were included in study with mean age value of 55.98+/- 13.47. The mean value of total cholesterol level was 175 mg/dl +/- 62.48. The LDL cholesterol level was 109.53mg/ dl +/- 35.67. The mean HDL cholesterol level was 42.14 mg/dl +/- 8.05, mean triglycerides level was 168.85 mg/ dl +/- 75.63. There were 23.7% patients with high total cholesterol (> 240 mg/dl), 18.75%patients (18.75%) with high and very high LDL cholesterol level (> 160 mg/dl), 46.25% patients with low HDL cholesterol level (< 40 mg/dl). The number of patients with high / very high triglycerides level (> 200 mg/dl or 500 mg/dl) were 21.25% patients The number of patients with optimal lipid level, 76.25% patients total cholesterol level < 240 mg/dl was patients ; 81.25% of patients had LDL cholesterol level < 160 mg/dl, 53.75% of patients had HDL cholesterol level > 40 mg/dl, 78.75%patients had triglycerides level < 200 mg/dl.
Atherogenic lipid profile is one the more common risk factor in ACS patients than other non lipid factors.This study demonstrated that atherogenic lipid is most commonly found in patients with Decreased HDL cholesterol level. Hence more attention needs to be paid to serum lipid and other modifiable risk factors in prevention of AMI and advice regarding good dietary habits and exercise to prevent such events at community level.
研究首次诊断为急性心肌梗死（AMI）患者的血脂谱模式。
本研究为 2020 年 9 月至 2021 年 10 月在三级保健医院进行的横断面研究。共纳入 80 名年龄> 18 岁的首次诊断为急性心肌梗死的患者，并在知情同意后纳入研究。通过患者病史、心电图、心脏生物标志物诊断为急性心肌梗死。排除患有甲状腺功能亢进症且已服用降脂药的患者。
80 例患者中，男性 62 例（77.5%），女性 18 例（22.5%）。66 例患者被诊断为 ST 段抬高型心肌梗死（STEMI）（82.50%），14 例患者为非 ST 段抬高型心肌梗死（NSTEMI）（17.5%）。研究纳入了年龄> 18 岁的患者，平均年龄为 55.98 ± 13.47 岁。总胆固醇水平平均值为 175 mg/dl ± 62.48。LDL 胆固醇水平为 109.53mg/dl ± 35.67。HDL 胆固醇水平平均值为 42.14mg/dl ± 8.05，甘油三酯水平平均值为 168.85mg/dl ± 75.63。23.7%的患者总胆固醇水平> 240mg/dl（高胆固醇血症），18.75%的患者 LDL 胆固醇水平> 160mg/dl（高和极高 LDL 胆固醇血症），46.25%的患者 HDL 胆固醇水平< 40mg/dl（低 HDL 胆固醇血症）。高/极高甘油三酯血症（> 200mg/dl 或> 500mg/dl）患者比例为 21.25%。血脂水平最佳的患者比例为 76.25%，总胆固醇水平< 240mg/dl；81.25%的患者 LDL 胆固醇水平< 160mg/dl；53.75%的患者 HDL 胆固醇水平> 40mg/dl；78.75%的患者甘油三酯水平< 200mg/dl。
与其他非脂类因素相比，致动脉粥样硬化血脂谱是 ACS 患者的常见危险因素之一。本研究表明，致动脉粥样硬化的血脂最常见于 HDL 胆固醇水平降低的患者。因此，在预防 AMI 时，需要更加关注血清脂质和其他可改变的危险因素，并在社区层面就良好的饮食习惯和运动提供建议，以预防此类事件的发生。
Zotero 插件