Aiims, Bathinda, Fazilka.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Hypertension has become a major health burden globally. The epidemiological transit to the non communicable disease era has shifted our focus to identify the risk factors and complications associated with each disease so that we can tackle the ongoing menace at the earliest. QT interval has long been associated with ventricular arrythmias and sudden cardiac deaths and the association between the QT interval in healthy subjects and diabetics have been extensively studied, but the association between QT interval and newly diagnosed hypertensive patients have been understudied.
The study included 100 newly diagnosed hypertensive patients who were willing to be a part of the study and providing informed consent whereas patients who were pregnant, below 18 years of age, mental health conditions which could affect their ability to comprehend and respond and patients suffering from any conditions such as myocardial infarction (MI), stroke, acute renal failure (ARF), liver disease, thyroid disorders, malignancy and those on antihypertensive treatment, drugs effecting QT interval were excluded from the study.
Mean BMI was 27.17 with max being 43.45 and minimum being 11.75 (Males: 27.41 and females 26.8). Waist circumference in more in females as compared to males whereas the hip circumference was almost same in both males and females. Age wise distribution showed increasing SBP and DBP values with age. Mean SBP and DBP was higher in males as compared to females whereas FBS was more in females as compared to males. QT values were more in the females as compared to males. BMI, waist circumference, hip circumference, W/H ratio had a positive correlation with both SBP and DBP.
The subjects with hypertension had relatively longer QTc interval and higher prevalence of prolonged QTc interval. Patients presenting in OPD must be looked for QTc and QTd so that risk of developing Arrythmias could be detected at early stages, thereby reducinfgmorbidity and mortality.
高血压已成为全球主要的健康负担。非传染性疾病时代的流行病学转变使我们将重点转移到识别与每种疾病相关的风险因素和并发症上，以便尽早应对这一持续存在的威胁。QT 间期一直与室性心律失常和心脏性猝死有关，健康受试者的 QT 间期与糖尿病患者的 QT 间期之间的关系已得到广泛研究，但 QT 间期与新诊断的高血压患者之间的关系尚未得到充分研究。
该研究纳入了 100 名新诊断的高血压患者，他们愿意参与研究并提供知情同意，而那些怀孕、年龄在 18 岁以下、心理健康状况可能影响他们理解和反应能力的患者，以及患有心肌梗死（MI）、中风、急性肾功能衰竭（ARF）、肝脏疾病、甲状腺疾病、恶性肿瘤和正在接受降压治疗的患者，以及影响 QT 间期的药物，均被排除在研究之外。
平均 BMI 为 27.17，最高为 43.45，最低为 11.75（男性：27.41，女性：26.8）。女性的腰围大于男性，而男性和女性的臀围几乎相同。按年龄分布，收缩压和舒张压值随年龄增长而增加。男性的平均 SBP 和 DBP 高于女性，而女性的 FBS 高于男性。女性的 QT 值高于男性。BMI、腰围、臀围、W/H 比值与 SBP 和 DBP 呈正相关。
高血压患者的 QTc 间期相对较长，且 QTc 间期延长的发生率较高。门诊就诊的患者必须检查 QTc 和 QTd，以便早期发现心律失常的风险，从而降低发病率和死亡率。
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