SMS Medical College, Jaipur.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Rheumatoid arthritis (RA) is a most common progressive, multi-systemic autoimmune disease characterized by chronic inflammation of multiple joints with associated systemic manifestations. RA has an estimated prevalence of 0.5 -1% of the adult population worldwide and is a leading cause of chronic morbidity and mortality in the industrialized world.A systematic analysis with RA showed 76% had one or more extra-articular feature. Thyroid hormone dysfunction and /or autoimmune thyroid disease were present in 6% to 33% patients with Rheumatoid Arthritis.
We conducted a hospital based observational, descriptive study from July 2018 until the number of sample are met.
260 RA patients who are attendind OPD & IPD, that meet inclusion and exclusion criteria.
The present study included the patients ranging from 15 years to above 65 years. It was observed that maximum cases were in the age group of 35-45 years (37.31%). The mean age of the study participants was 40.80±10.91years. In the present study we found that rheumatoid arthritis was more common in females 212 (81.54%) than the male cases 48(18.46%). In the present study we found that thyroid dysfunction is observed in 20% of patients. The most common thyroid dysfunction observed was overt hypothyroidism seen in 10.77% of the patients followed by subclinical hypothyroidism seen in 8.46% and subclinical hyperthyroidism 0.77% of patients. Anti-TPO antibodies were seen in 82.14% of patients with clinically overt hypothyroidism.
Majority of the cases of rheumatoid arthritis are in the age group of 40.80 ±10.91 years and females account for the majority of the cases of rheumatoid arthritis. In our study thyroid dysfunction are observed in 20% of patients. Prevalence of thyroid dysfunctions in rheumatoid arthritis is high and associated with thyroid autoimmunity and suggested that all rheumatoid arthritis patients should go for thyroid functions.
类风湿关节炎（RA）是一种最常见的进行性、多系统自身免疫性疾病，其特征为慢性多关节炎症伴发全身表现。RA 在全球成年人中的患病率估计为 0.5-1%，是工业化国家导致慢性发病率和死亡率的主要原因。一项针对 RA 的系统分析显示，76%的患者存在 1 个或多个关节外表现。甲状腺激素功能障碍和/或自身免疫性甲状腺疾病在 6%-33%的 RA 患者中存在。
我们进行了一项基于医院的观察性、描述性研究，从 2018 年 7 月至样本量达到为止。
260 名符合纳入和排除标准的 RA 门诊和住院患者。
本研究纳入的患者年龄在 15 岁以上，最大年龄组为 35-45 岁（37.31%）。研究参与者的平均年龄为 40.80±10.91 岁。在本研究中，我们发现女性 RA 患者 212 例（81.54%）多于男性患者 48 例（18.46%）。在本研究中，我们发现 20%的患者存在甲状腺功能障碍。观察到最常见的甲状腺功能障碍是显性甲状腺功能减退症，占患者的 10.77%，其次是亚临床甲状腺功能减退症，占 8.46%，亚临床甲状腺功能亢进症占 0.77%。抗甲状腺过氧化物酶抗体在临床上显性甲状腺功能减退症患者中占 82.14%。
大多数 RA 病例的年龄在 40.80±10.91 岁之间，女性占 RA 病例的大多数。在我们的研究中，20%的患者存在甲状腺功能障碍。RA 患者甲状腺功能障碍的患病率较高，与甲状腺自身免疫有关，并提示所有 RA 患者均应进行甲状腺功能检查。
