Kalinga Institute of Medical Sciences, Bhubaneswar.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
The ongoing COVID-19 pandemic has thrown newer challenges for the health care professionals to manage the affected patients. Though the so called second wave is in a declining trend at present but possible third wave is looming in the near future. Initially patients appeared to have a respiratory limited disease but there are now increasing reports of multiple organ involvement including renal disease in association with COVID-19. The current study aims to highlight the incidence of acute kidney injury (AKI) in COVID-19 patients, as well as the clinical profile and outcomes in that subset of patients in a tertiary hospital setting, in order to better understand the role renal disease plays in the disease process.
Methods: This retrospective, observational study involved a review of data from electronic health records of patients aged more than 18 years with laboratory confirmed COVID-19 admitted to our hospital from February 27 to May 30, 2021. Data was analysed using SPSS version-21.0 by descriptive statistics. We describe the incidence of AKI, dialysis requirement, requirement of mechanical ventilation and mortality.
Results of 400 hospitalized patients with COVID-19, 252(63%) were male, 148(37%) were female. AKI occurred in 72 (18%) patients. The proportions with stages 1, 2, or 3 AKI were 35(48.3%), 11 (15.1%), and 26 (36.6%), respectively. 22 (32%) patients with AKI required dialysis. About 42(58.33%) patients with AKI were admitted in Intensive care Unit and 35(48%) patients with AKI required mechanical ventilation. In-hospital mortality was (25%) among patients with AKI versus (7.01%) among those without AKI (OR, 4.42; 95% confidence interval, 2.23 to 8.73).
Conclusions AKI is common among patients hospitalized with COVID-19 and is associated with high morbidity and mortality.
本回顾性观察研究分析了 2021 年 2 月 27 日至 5 月 30 日期间在我院住院的年龄大于 18 岁且实验室确诊为 COVID-19 的患者的电子病历数据，旨在探讨 COVID-19 患者急性肾损伤（AKI）的发生率以及该亚组患者的临床特征和结局，以便更好地了解肾脏疾病在疾病进程中的作用。
本回顾性观察研究分析了 2021 年 2 月 27 日至 5 月 30 日期间在我院住院的年龄大于 18 岁且实验室确诊为 COVID-19 的患者的电子病历数据，旨在探讨 COVID-19 患者急性肾损伤（AKI）的发生率以及该亚组患者的临床特征和结局，以便更好地了解肾脏疾病在疾病进程中的作用。
在 400 例住院 COVID-19 患者中，252 例（63%）为男性，148 例（37%）为女性。72 例（18%）患者发生 AKI。AKI 患者中，1 期、2 期和 3 期 AKI 的比例分别为 35%（48.3%）、11%（15.1%）和 26%（36.6%）。22 例（32%）AKI 患者需要透析。AKI 患者中，42 例（58.33%）收入重症监护病房，35 例（48%）需要机械通气。AKI 患者的院内死亡率为 25%，无 AKI 患者的院内死亡率为 7.01%（OR，4.42；95%CI，2.23 至 8.73）。
AKI 在 COVID-19 住院患者中很常见，与高发病率和死亡率相关。
