RNT Medical College, Jhajjar, Udaipur.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
At the end of 2019, a novel coronavirus was identified as the cause of a cluster of pneumonia cases in Wuhan, a city in the Hubei Province of China. It rapidly spread throughout the world. Identifying patients at highest risk for severe disease is important to facilitate early, aggressive intervention and to mitigate the crises occurring throughout the world. Biomarkers were needed for patient stratification into those likely to develop severe disease and with high risk of mortality. Present study aims to find out those indicators.
Total patients admitted over a period of 1 year from 1st April 2020 to 31th March 2021 in Dedicated COVID Hospital of RNT Medical College and MB hospital Udaipur was 4304 out of which 620 died and 3498 got discharged, 186 couldn't be followed up as they took leave against medical advise. From death group (620 patients) and Survival group (3498 patients), 400 patients were selected randomly from each group and were analysed and comparison was made between both the groups including parameters like ALC(Absolute lymphocyte count), NLR(Neutrophil Lymphocyte)ratio and RDW(Red cell distribution width).
Median age in death and survival group was 62.03 and 47.18 respectively. Mean Absolute lymphocyte count was 0.88 and 0.93 in death and survival group respectively. Mean Neutrophil -Lymphocyte ratio in death and survival group was 8.37 and 4.34 respectively. Mean RDW- CV was 1.86 and 1.67 in death and survival group respectively.
From the present study we conclude that Decreased ALC and Elevated NLR are a reliable indicator of death as an outcome in COVID 19 disease whereas RDW was high in COVID19 patients but had no significant relationship with outcome of the disease.
本研究旨在寻找相关指标。
2020 年 4 月 1 日至 2021 年 3 月 31 日期间，在 RNT 医学院和乌代浦 MB 医院的专门 COVID 医院住院治疗的患者中，共有 4304 例患者，其中 620 例死亡，3498 例出院，186 例因擅自离院而无法随访。从死亡组（620 例患者）和存活组（3498 例患者）中随机选择 400 例患者进行分析，并对两组患者的参数进行比较，包括绝对淋巴细胞计数（ALC）、中性粒细胞-淋巴细胞比值（NLR）和红细胞分布宽度（RDW）。
死亡组和存活组的中位年龄分别为 62.03 岁和 47.18 岁。死亡组和存活组的平均绝对淋巴细胞计数分别为 0.88 和 0.93。死亡组和存活组的平均中性粒细胞-淋巴细胞比值分别为 8.37 和 4.34。死亡组和存活组的平均 RDW-CV 分别为 1.86 和 1.67。
从本研究中我们得出结论，降低的 ALC 和升高的 NLR 是 COVID-19 疾病死亡结局的可靠指标，而 RDW 在 COVID-19 患者中升高，但与疾病结局无显著关系。
