Government Medical College and Hospital, Chandigarh.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Chronic liver disease (CLD) patients develop portal hypertension which lead to complications like splenomegaly, ascites and esophageal varices. Portal hypertension is defined as hepatic venous pressure gradient more than 5mmHg, being invasive it is difficult to measure. Some studies show that increased portal vein diameter (PVD) on ultrasonography correlate with oesophageal varices and can indicate portal hypertension. Studies correlating PVD with other complications of portal hypertension like ascites and spleen size are lacking. Aim of this study was to correlate portal vein diameter with ascites, spleen size, thrombocytopenia and prognostic markers like Child-Turcotte Pugh (CTP) score and Model for End stage Liver Disease (MELD) score in Chronic liver disease patients.
This was a cross-sectional observational study of patients with Chronic liver disease conducted at tertiary care teaching hospital. All patient underwent clinical history, examination, blood testing and ultrasonography. Data collected was analysed by using statistical tests.
Out of 97 CLD patients taken in study, the mean age of patients was 47.39 ± 12.64 year and majority were male (75.3%). Most common etiological factor was alcohol (in 53.7%). On clinical examination, 55.7% patients had pallor, 54.6% had icterus. Chest radiograph shows pleural effusion in 14.4% patients. Mean portal vein diameter was found to be 12.31 ± 2.71mm. Correlation coefficient of portal vein diameter with spleen size was 0.3 with p value of 0.004 suggesting a positive correlation. Parameters like thrombocytopenia, CTP score and MELD score correlation coefficient was -0.2(p-value: 0.066), 0.1(p value: 0.463) and 0.0(p-value: 0.725) respectively. The mean of PVD(mm) in ascites group was 12.43 and non ascites group was 11.92. Strength of association was 0.08 (Point Biserial correlation) indicating no association.
Portal vein diameter had positive correlation with spleen size which is statistically significant in our study. No significant correlation was observed between PVD with ascites, thrombocytopenia, CTP score and MELD score.
本研究旨在探讨门静脉直径与慢性肝病患者腹水、脾肿大、血小板减少症以及预后标志物（如 Child-Turcotte Pugh 评分和终末期肝病模型评分）之间的相关性。
这是一项在三级教学医院进行的慢性肝病患者的横断面观察性研究。所有患者均接受了临床病史、检查、血液检查和超声检查。收集的数据通过统计检验进行分析。
在纳入研究的 97 例慢性肝病患者中，患者的平均年龄为 47.39±12.64 岁，大多数为男性（75.3%）。最常见的病因是酒精（占 53.7%）。在临床检查中，55.7%的患者出现苍白，54.6%的患者出现黄疸。胸部 X 光片显示 14.4%的患者有胸腔积液。平均门静脉直径为 12.31±2.71mm。门静脉直径与脾大小的相关系数为 0.3，p 值为 0.004，提示存在正相关。血小板减少症、CTP 评分和 MELD 评分的相关系数分别为-0.2（p 值：0.066）、0.1（p 值：0.463）和 0.0（p 值：0.725）。腹水组的平均 PVD（mm）为 12.43，非腹水组为 11.92。关联强度为 0.08（点双列相关），表明无关联。
门静脉直径与脾大小呈正相关，在本研究中具有统计学意义。PVD 与腹水、血小板减少症、CTP 评分和 MELD 评分之间未观察到显著相关性。
