Wang Yu, Cao Yalan, Xiang Shuting, Liang Shunji, Yang Xiumei, Zhu Ning, Fang Weiyi, Yu Qin
Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Department of Nephrology, Affiliated Xinhua Hospital of Dalian University, Dalian, China.
Front Physiol. 2022 Apr 4;13:655827. doi: 10.3389/fphys.2022.655827. eCollection 2022.
To explore the correlation between characteristics of myocardial energy expenditure (MEE) and the degree of diastolic dysfunction in patients of heart failure with preserved ejection fraction (HFpEF) and its clinical significance. 125 consecutive patients diagnosed with HFpEF in the Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University from January 2018 to October 2018 were enrolled. According to the degree of diastolic dysfunction, patients were divided into group A (8 ≤ E/e' ≤15) and group B (E/e'> 15), and MEE was calculated, patients finished 1-year clinical follow-up. The level of MEE in group A was significantly lower than that in group B ( < 0.05). During 1-year follow up, MEE over 3145.69 kcal/systole was associated with increased risk of death as compared to patients with MEE less 3145.69 kcal/systole, and in patients with MEE over 101.68 kcal/min than in patients with MEE less than 101.68 kcal/min. There is a significant correlation between MEE and diastolic dysfunction and MEE over 3145.69 kcal/systole as well as MEE over 101.68 kcal/min are linked with increased risk of 1-year mortality in HFpEF.
探讨射血分数保留的心力衰竭（HFpEF）患者心肌能量消耗（MEE）特征与舒张功能障碍程度之间的相关性及其临床意义。选取2018年1月至2018年10月在大连大学附属中山医院心内科连续诊断为HFpEF的125例患者。根据舒张功能障碍程度，将患者分为A组（8≤E/e'≤15）和B组（E/e'>15），计算MEE，患者完成1年临床随访。A组MEE水平显著低于B组（<0.05）。在1年随访期间，与MEE低于3145.69千卡/收缩期的患者相比，MEE超过3145.69千卡/收缩期的患者死亡风险增加，且MEE超过101.68千卡/分钟的患者比MEE低于101.68千卡/分钟的患者死亡风险增加。MEE与舒张功能障碍之间存在显著相关性，MEE超过3145.69千卡/收缩期以及MEE超过101.68千卡/分钟与HFpEF患者1年死亡风险增加相关。
