Wei Ziqi, Ye Xiaolai, Wang Changquan, Xu Jiwen, Zhang Puming, Liu Qiangqiang, Zhao Jun
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Department of Neurosurgery, Clinical Neuroscience Center Comprehensive Epilepsy Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Neurol. 2022 Apr 4;13:864070. doi: 10.3389/fneur.2022.864070. eCollection 2022.
Familial lateral temporal lobe epilepsy (FLTLE) is genetic focal epilepsy usually characterised by auditory symptoms. Most FLTLE cases can be controlled by anti-seizure medications, and to our best knowledge, there are no previous reports about stereoelectroencephalography (SEEG) used for patients with FLTLE. In this report, we present two patients with FLTLE in one family and their SEEG performances, together with F-fluorodeoxyglucose (F-FDG) PET and MRI results. In case 1, fast activities originated from the right superior temporal gyrus and spread rapidly to the right anterior insular lobe and hippocampus. In case 2, there were two seizure patterns: (1) The fast activities or sharp slow waves were identified at the left superior temporal gyrus, then, sharp waves and spike waves spread in the left superior temporal gyrus; (2) There were fast activities and slow-wave oscillation originated in the left superior temporal gyrus, then, the fast activities spread in the left superior temporal gyrus and finally spread to the other sites. An SEEG-guided radiofrequency thermocoagulation was performed for both patients and one of them underwent resection surgery. Seizures are well-controlled and the patients are very satisfied with the therapeutic effects.
家族性外侧颞叶癫痫（FLTLE）是一种遗传性局灶性癫痫，通常以听觉症状为特征。大多数FLTLE病例可通过抗癫痫药物控制，据我们所知，此前尚无关于将立体定向脑电图（SEEG）用于FLTLE患者的报道。在本报告中，我们介绍了一个家族中的两名FLTLE患者及其SEEG表现，以及氟脱氧葡萄糖（F-FDG）PET和MRI结果。病例1中，快速活动起源于右侧颞上回，并迅速扩散至右侧前岛叶和海马体。病例2有两种发作模式：（1）在左侧颞上回发现快速活动或尖慢波，随后尖波和棘波在左侧颞上回扩散；（2）快速活动和慢波振荡起源于左侧颞上回，随后快速活动在左侧颞上回扩散，最终扩散至其他部位。对两名患者均进行了SEEG引导下的射频热凝治疗，其中一名患者接受了切除术。癫痫发作得到了很好的控制，患者对治疗效果非常满意。
