Galijašević Malik, Dervišević Amela, Fajkić Almir, Avdagić Nesina, Suljević Damir
University Clinic for Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria.
University of Sarajevo, Medical Faculty, Department of Human Physiology, Sarajevo, Bosnia and Herzegovina.
Curr Health Sci J. 2021 Oct-Dec;47(4):566-574. doi: 10.12865/CHSJ.47.04.13. Epub 2021 Dec 31.
Different qualitative and quantitative changes in platelets are involved in the pathophysiological processes in inflammatory bowel diseases (IBD): ulcerative colitis (UC) and Crohn's disease (CD). The aim of the study was to determine the diagnostic accuracy of Platelet mass Index (PMI) and other platelet parameters in assessment disease activity in patients with UC and CD. A cross-sectional, observational study consisted of 60 IBD patients (30 UC and 30 CD) and 30 healthy subjects (Control group). Patients were grouped according to disease activity into active and inactive (remission). Platelet count (PLC), Plateletcrit (PCT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and PMI were determined for all study participants. Receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine diagnostic accuracy. Although PLC had the highest AUC (0.756) compared to PCT (AUC: 0.731), PDW (AUC: 0.722) and PMI (AUC: 0.724), they all had fair diagnostic accuracy in distinguishing active and inactive UC patients. Discriminatory accuracy of PLC was excellent (AUC: 0.909), PCT and PMI good to excellent (AUC: 0.809 and AUC: 0.893, respectively) and PDW fair (AUC: 0.789) in classifying CD patients as active and inactive. Platelet parameters are simple, routinely available biomarkers more useful for assessing disease activity for patients with CD than for patients with UC. Our results indicate, for the first time, that PMI may serve as a novel and simple marker in identifying whether IBD patients are in the active or inactive phase of the disease.
血小板的不同定性和定量变化参与了炎症性肠病（IBD），即溃疡性结肠炎（UC）和克罗恩病（CD）的病理生理过程。本研究的目的是确定血小板质量指数（PMI）和其他血小板参数在评估UC和CD患者疾病活动度方面的诊断准确性。一项横断面观察性研究纳入了60例IBD患者（30例UC和30例CD）和30名健康受试者（对照组）。患者根据疾病活动度分为活动期和非活动期（缓解期）。测定了所有研究参与者的血小板计数（PLC）、血小板压积（PCT）、平均血小板体积（MPV）、血小板分布宽度（PDW）和PMI。采用受试者工作特征（ROC）曲线及其相应的曲线下面积（AUC）来确定诊断准确性。尽管与PCT（AUC：0.731）、PDW（AUC：0.722）和PMI（AUC：0.724）相比，PLC的AUC最高（0.756），但它们在区分活动期和非活动期UC患者方面都具有尚可的诊断准确性。在将CD患者分为活动期和非活动期方面，PLC的鉴别准确性极佳（AUC：0.909），PCT和PMI良好至极佳（分别为AUC：0.809和AUC：0.893），PDW尚可（AUC：0.789）。血小板参数是简单、常规可得的生物标志物，但对于评估CD患者的疾病活动度比UC患者更有用。我们的结果首次表明，PMI可能作为一种新颖且简单的标志物，用于识别IBD患者处于疾病的活动期还是非活动期。
