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磁共振成像在检测皮质发育异常中的重要性。

The Importance of Magnetic Resonance in Detection of Cortical Dysplasia.

作者信息

Hyseni Fjolla, Ahmetgjekaj Ilir, Vokshi Valon, Mamillo Keti, Biba Valbona, Shaipi Blerona, Brati Migena, Dedushi Kreshnike, Shatri Jeton, Aliu Ermira, Guy Ali, Salihaj Kristi, Berisha Rexhep, Musa Juna

机构信息

Medical Researcher, NYU Langone Health, New York, USA.

Clinic of Radiology, University Clinical Center of Kosovo, Albania.

出版信息

Curr Health Sci J. 2021 Oct-Dec;47(4):585-589. doi: 10.12865/CHSJ.47.04.16. Epub 2021 Dec 31.

Abstract

Focal cortical dysplasia is a malformation of cortical development in which there are abnormalities with cortical lamination, neuronal maturation, and neuronal differentiation. It is the most common cause of medically refractory epilepsy in the pediatric population and the second/third most common etiology of medically intractable seizures in adults. Herein, we present the case of 23-years-old female patient, presenting with loss of consciousness, and convulsions. A MRI revealed a 5mm cortical thickening on either side of the posterior aspect of the right superior temporal gyrus without transmantle extension towards ventricle. This abnormal area is measured about 24x16mm and there was no evidence for mesial temporal sclerosis. Both hippocampi are normal is size, morphology and signal. These features are consistent with cortical dysplasia type 1. This case report emphasizes the importance of MRI in the detection of FCD. MRI can show no abnormalities in type 1 FCD, but when the changes are apparent, they are on the temporal lobe, and seizures presents most commonly in adults.

摘要

局灶性皮质发育不良是一种皮质发育畸形,其特征为皮质分层、神经元成熟和神经元分化存在异常。它是儿科人群药物难治性癫痫最常见的病因,也是成人药物难治性癫痫第二/第三常见的病因。在此,我们报告一例23岁女性患者,表现为意识丧失和抽搐。磁共振成像(MRI)显示右侧颞上回后部两侧皮质增厚5毫米,未向脑室跨壁延伸。这个异常区域大小约为24×16毫米,没有内侧颞叶硬化的证据。双侧海马体在大小、形态和信号方面均正常。这些特征符合1型皮质发育不良。本病例报告强调了MRI在检测局灶性皮质发育不良中的重要性。MRI在1型局灶性皮质发育不良中可能显示无异常,但当变化明显时,病变位于颞叶,且癫痫最常见于成人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f38a/8987480/2c18189cb3c5/CHSJ-47-04-585-fig1.jpg

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