Wilms H, Keller F, Hasselmann J, Hantelmann W, Offermann G
Z Urol Nephrol. 1986 Oct;79(10):545-8.
Antibiotic prophylaxis in kidney transplantation is controversial. In a prospective controlled study, 34 cadaveric kidney transplant recipients were investigated. Antibiotic prophylaxis was given in a random order to 16 patients whereas 18 without prophylaxis served as controlls. In 4 of 20 investigated clinical parameters statistically significant differences were found between both groups: the controlls happened to have better initial conditions; perioperative and postoperative better initial conditions; perioperative and postoperative infections were less frequent in the prophylaxis group and more antibiotics postoperatively were needed in the controlls. These findings indicate that antibiotic prophylaxis has a beneficial effect in kidney transplantation.
肾移植中的抗生素预防存在争议。在一项前瞻性对照研究中,对34例尸体肾移植受者进行了调查。16例患者随机接受抗生素预防,而18例未接受预防的患者作为对照。在20项研究的临床参数中,两组之间有4项存在统计学显著差异:对照组的初始状况更好;围手术期和术后的初始状况更好;预防组的围手术期和术后感染较少,而对照组术后需要更多抗生素。这些发现表明抗生素预防在肾移植中具有有益作用。