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粘连性小肠梗阻开放手术与腹腔镜手术的临床结局和安全性比较:一项基于国家住院患者数据库的倾向评分匹配分析

Comparison of Clinical Outcomes and Safety Between Open and Laparoscopic Surgery for Adhesive Small Bowel Obstruction: A Propensity-Matched Analysis of a National Inpatient Database.

作者信息

Yamamoto Yuta, Kitazawa Masato, Otsubo Tetsuya, Miyagawa Yusuke, Tokumaru Shigeo, Nakamura Satoshi, Koyama Makoto, Ehara Takehito, Hondo Nao, Iijima Yasuhiro, Soejima Yuji

机构信息

Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.

The Database Center of the National University Hospitals, The University of Tokyo Hospital, Tokyo, Japan.

出版信息

J Laparoendosc Adv Surg Tech A. 2022 Oct;32(10):1064-1070. doi: 10.1089/lap.2022.0050. Epub 2022 Apr 19.

Abstract

The effectiveness of laparoscopic surgery for adhesive small bowel obstruction (ASBO) remains unclear. We aimed to compare the outcomes and safety of open and laparoscopic surgeries for ASBO. In this retrospective study, we analyzed an inpatient database of 42 national university hospitals in Japan. Patients who underwent surgery for the first episode of ASBO between April 2013 and March 2018 were identified. Using the propensity score method, patients who underwent laparoscopic surgery were matched one-to-one with those who underwent open surgery. We investigated postoperative clinical outcomes, including morbidity, mortality, length of hospital stay (LOS), and recurrence. Overall, 306 and 96 patients underwent open and laparoscopic surgery, respectively (96 propensity score-matched pairs). The incidence rates of postoperative morbidity, mortality, and recurrence were comparable between the two groups. Cox regression analysis revealed a hazard ratio (HR) of 1.020 ( = .959) for readmission due to ASBO in the laparoscopic surgery group relative to the open surgery group. Postoperative hospital stay was longer for open surgery than for laparoscopic surgery (13.0 days versus 10.0 days,  < .001). Cox regression analysis revealed that laparoscopic surgery was associated with earlier postoperative discharge compared with open surgery (HR 1.641,  = .002). The postoperative LOS was shorter with laparoscopic surgery than with open surgery for ASBO, but there were no differences between the procedures in other clinical outcomes. Laparoscopic surgery is suitable to treat patients with ASBO.

摘要

腹腔镜手术治疗粘连性小肠梗阻(ASBO)的有效性仍不明确。我们旨在比较ASBO开放手术和腹腔镜手术的疗效及安全性。在这项回顾性研究中,我们分析了日本42家国立大学医院的住院患者数据库。确定了2013年4月至2018年3月期间因ASBO首次发作而接受手术的患者。采用倾向评分法,将接受腹腔镜手术的患者与接受开放手术的患者进行一对一匹配。我们调查了术后临床结局,包括发病率、死亡率、住院时间(LOS)和复发情况。总体而言,分别有306例和96例患者接受了开放手术和腹腔镜手术(96对倾向评分匹配对)。两组术后发病率、死亡率和复发率相当。Cox回归分析显示,腹腔镜手术组因ASBO再次入院的风险比(HR)为1.020(95%CI = 0.959),相对于开放手术组。开放手术的术后住院时间比腹腔镜手术长(13.0天对10.0天,P < 0.001)。Cox回归分析显示,与开放手术相比,腹腔镜手术与术后更早出院相关(HR 1.641,95%CI = 0.002)。对于ASBO,腹腔镜手术的术后LOS比开放手术短,但在其他临床结局方面,两种手术方法之间没有差异。腹腔镜手术适合治疗ASBO患者。

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