Thivolet J, Viac J
Ann Dermatol Venereol. 1978 Mar;105(3):257-64.
Specific immune reactions in man subsequent to infection by wart virus have been the subject of various studies. Most concern humoral immunity and show an antibody distribution which rises with age comparable to the viral exanthems of childhood with a maximum at 20 years and show decline thereafter. The acquisition of antibody is prolonged and sometimes irregular and its role in wart healing is questionable. The most recent work on cellular immunity has demonstrated profound abnormalities in cases of profuse verrucosis and in epidermodysplasia verruciformis, increased incidence of warts in immunodeficient states and the existence of specific reactions to viral antigen both in vitro and in vivo. Such results indicate and predominant role for cellular immunity in the evolution of this viral infection and suggest the possibility of specific immunotherapy. Very recent studies of biochemical identification of purified virus particles of various clinical types of wart show viral heterogeneity. This fact implies the need to reexamine these immune reactions in the light of the existence of crossed serological reactivity and specific wart treatment.
人类感染疣病毒后的特异性免疫反应一直是各种研究的主题。大多数研究关注体液免疫，结果显示抗体分布随年龄增长而上升，与儿童期病毒疹类似，在20岁时达到峰值，此后呈下降趋势。抗体的获得过程漫长，有时并不规律，其在疣愈合过程中的作用也存在疑问。关于细胞免疫的最新研究表明，在疣状增殖症和疣状表皮发育不良病例中存在严重异常，免疫缺陷状态下疣的发病率增加，并且在体外和体内都存在对病毒抗原的特异性反应。这些结果表明细胞免疫在这种病毒感染的发展过程中起主要作用，并提示了特异性免疫治疗的可能性。最近对各种临床类型疣的纯化病毒颗粒进行生化鉴定的研究显示出病毒的异质性。这一事实意味着需要根据交叉血清反应性的存在和特异性疣治疗方法重新审视这些免疫反应。
