三种植物的乙醇提取物作为天然胃保护剂的评价：[具体植物名称未给出]及组织病理学研究
Evaluation of ethanol extracts from three species of as natural gastroprotective agents: and histopathological studies.
作者信息
Fitrya Fitrya, Amriani Annisa, Novita Rennie Puspa, Salsabila Aufa, Siregar Silvy Marina, Anafisya Yunike
机构信息
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya City, South Sumatera, Indonesia.
出版信息
J Complement Integr Med. 2022 Apr 21;19(4):967-974. doi: 10.1515/jcim-2022-0105. eCollection 2022 Dec 1.
OBJECTIVES
is a tropical plant known for its high concentration of secondary metabolites, especially flavonoids and phenolics. This study aims to evaluate the potential use of ethanol extracts obtained from three species of () as gastroprotective agents.
METHODS
The gastroprotective potential of the extracts at concentrations of 100, 200, and 400 mg/kg BW was studied in an animal model induced by absolute ethanol. The animals were subjected to extract pre-treatment for 14 days. Subsequently, the gastroprotective potential was evaluated based on the area of the lesion, the volume of gastric fluid, gastric pH, total acidity, gastric wall mucus content, and microscopic lesions.
RESULTS
There was a significant decrease in the lesion area and gastric fluid volume in the animals that received pre-treated extracts of , , and , as well as a significant increase in the pH and gastric wall mucus secretion when compared to the ethanol group (p<0.05), rather than the omeprazole or the normal group (p>0.05). Both macroscopic and microscopic examinations revealed a significant decrease in necrotic lesions.
CONCLUSIONS
Extracts of , , and are effective in lowering the risk of peptic ulcers since they have the potential to be used as natural gastroprotective agents.
目的
是一种热带植物，以其高浓度的次生代谢产物，尤其是黄酮类化合物和酚类物质而闻名。本研究旨在评估从三种（植物名称缺失）植物中获得的乙醇提取物作为胃保护剂的潜在用途。
方法
在绝对乙醇诱导的动物模型中，研究了浓度为100、200和400mg/kg体重的提取物的胃保护潜力。对动物进行提取物预处理14天。随后，根据损伤面积、胃液体积、胃pH值、总酸度、胃壁黏液含量和微观损伤来评估胃保护潜力。
结果
与乙醇组相比（p<0.05），接受预处理的（植物名称缺失）、（植物名称缺失）和（植物名称缺失）提取物的动物的损伤面积和胃液体积显著减少，pH值和胃壁黏液分泌显著增加，与奥美拉唑组或正常组相比（p>0.05）无显著差异。宏观和微观检查均显示坏死性病变显著减少。
结论
（植物名称缺失）、（植物名称缺失）和（植物名称缺失）的提取物可有效降低消化性溃疡的风险，因为它们有潜力用作天然胃保护剂。
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