Fielding C J
Am Heart J. 1987 Feb;113(2 Pt 2):532-7. doi: 10.1016/0002-8703(87)90627-2.
The transfer of cholesteryl esters generated by lecithin-cholesterol acyltransferase to low- and very low-density lipoproteins is greatly modified under different physiologic and pathologic conditions. A major factor determining transfer rates is the level of unesterified cholesterol in the acceptor lipoproteins. Low cholesteryl ester transfer rates are characteristic of several groups at increased risk for coronary artery disease. This appears to reflect a systematic abnormality of free cholesterol metabolism and transport in these groups.
卵磷脂胆固醇酰基转移酶生成的胆固醇酯向低密度脂蛋白和极低密度脂蛋白的转移在不同生理和病理条件下会发生很大改变。决定转移速率的一个主要因素是受体脂蛋白中未酯化胆固醇的水平。低胆固醇酯转移速率是几组冠心病风险增加人群的特征。这似乎反映了这些人群中游离胆固醇代谢和转运的系统性异常。
