FKBP39控制着（某种生物）幼虫阶段的保幼激素活性和发育。 （原文中“in.”后面缺少具体内容）
FKBP39 Controls the Larval Stage JH Activity and Development in .
作者信息
Wang Xinyu, Zhou Ying, Guan Jianwen, Cheng Yang, Lu Yingying, Wei Youheng
机构信息
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China.
出版信息
Insects. 2022 Mar 28;13(4):330. doi: 10.3390/insects13040330.
FK506-binding protein 39kD (FKBP39) localizes in the nucleus and contains multiple functional domains. Structural analysis suggests that FKBP39 might function as a transcriptional factor and control juvenile hormone (JH) activity. Here, we show that FKBP39 expresses at a high level and localizes in the nucleolus of fat body cells during the first two larval stages and early third larval stage. The mutant displays delayed larval-pupal transition and an increased expression of , the main mediator of the JH pathway, at the early third larval stage. Moreover, the mutant has a fertility defect that is independent of JH activity. Interestingly, the expression of , the most widely used reference gene for qRT-PCR in Drosophila, significantly decreased in the mutant, suggesting that FKBP39 might regulate ribosome assembly. Taken together, our data demonstrate the expression pattern and physiological roles of FKBP39 in Drosophila.
FK506结合蛋白39kD（FKBP39）定位于细胞核，包含多个功能域。结构分析表明，FKBP39可能作为转录因子发挥作用并控制保幼激素（JH）活性。在此，我们发现FKBP39在前两个幼虫阶段和第三幼虫早期阶段在脂肪体细胞的核仁中高水平表达且定位于此。该突变体在第三幼虫早期阶段显示幼虫-蛹转变延迟，并且JH途径的主要介质的表达增加。此外，该突变体存在与JH活性无关的生育缺陷。有趣的是，在果蝇中qRT-PCR最广泛使用的参考基因的表达在该突变体中显著降低，表明FKBP39可能调节核糖体组装。综上所述，我们的数据证明了FKBP39在果蝇中的表达模式和生理作用。
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