Spital A, Panner B J, Sterns R H
Am J Kidney Dis. 1987 Jan;9(1):71-8. doi: 10.1016/s0272-6386(87)80165-8.
Two patients who presented with severe renal failure and evidence of generalized proximal tubular dysfunction were found to have severe diffuse acute tubulointerstitial nephritis on renal biopsy. No etiology could be found in either case. Both patients had dramatic improvement in renal function following steroid therapy. In the first reported case of its kind, one patient relapsed when steroids were withdrawn, but improved again with reinstitution of steroid therapy. These cases, as well as others in the literature, show that steroids are effective and may be necessary to improve renal function in some patients with acute idiopathic tubulointerstitial nephritis. Evidence of proximal tubular dysfunction is a clue to the presence of this disorder.
两名出现严重肾衰竭及全身性近端肾小管功能障碍证据的患者，经肾活检发现患有严重弥漫性急性肾小管间质性肾炎。两例均未找到病因。两名患者在接受类固醇治疗后肾功能均有显著改善。在首例此类报告病例中，一名患者停用类固醇后复发，但再次使用类固醇治疗后又有所改善。这些病例以及文献中的其他病例表明，类固醇对改善某些急性特发性肾小管间质性肾炎患者的肾功能有效且可能是必要的。近端肾小管功能障碍的证据是该疾病存在的一个线索。
