Welch Morgan, Secunda Cassandra, Ghimire Nabin, Martinez Isabel, Mathus Amber, Patel Urja, Bhogoju Sarayu, Al-Mutairi Mashael, Min Kisuk, Lawan Ahmed
Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA.
Membranes (Basel). 2022 Apr 9;12(4):410. doi: 10.3390/membranes12040410.
Obesity has reached global epidemic proportions and it affects the development of insulin resistance, type 2 diabetes, fatty liver disease and other metabolic diseases. Membrane lipids are important structural and signaling components of the cell membrane. Recent studies highlight their importance in lipid homeostasis and are implicated in the pathogenesis of fatty liver disease. Here, we discuss the numerous membrane lipid species and their metabolites including, phospholipids, sphingolipids and cholesterol, and how dysregulation of their composition and physiology contribute to the development of fatty liver disease. The development of new genetic and pharmacological mouse models has shed light on the role of lipid species on various mechanisms/pathways; these lipids impact many aspects of the pathophysiology of fatty liver disease and could potentially be targeted for the treatment of fatty liver disease.
肥胖已达到全球流行程度，它影响胰岛素抵抗、2型糖尿病、脂肪性肝病和其他代谢性疾病的发展。膜脂是细胞膜重要的结构和信号成分。最近的研究突出了它们在脂质稳态中的重要性，并与脂肪性肝病的发病机制有关。在这里，我们讨论了众多的膜脂种类及其代谢产物，包括磷脂、鞘脂和胆固醇，以及它们的组成和生理失调如何导致脂肪性肝病的发展。新的遗传和药理小鼠模型的开发揭示了脂质种类在各种机制/途径中的作用；这些脂质影响脂肪性肝病病理生理学的许多方面，并且有可能成为治疗脂肪性肝病的靶点。
