Department of General Surgery, Tangdu Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
Department of General Surgery, The 75th Group Army Hospital, Dali, China.
Cell Death Dis. 2022 Apr 21;13(4):394. doi: 10.1038/s41419-022-04848-z.
Primary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA). Recent studies have indicated that there are differences in cancer stem cell (CSC) properties among different types of liver cancer. Liver cancer stem cells (LCSCs), also called liver tumor-initiating cells, have been viewed as drivers of tumor initiation and metastasis. Many mechanisms and factors, such as mitophagy, mitochondrial dynamics, epigenetic modifications, the tumor microenvironment, and tumor plasticity, are involved in the regulation of cancer stemness in liver cancer. In this review, we analyze cancer stemness in different liver cancer types. Moreover, we further evaluate the mechanism of cancer stemness maintenance of LCSCs and discuss promising treatments for eradicating LCSCs.
肝细胞癌（HCC）、胆管细胞癌（CCA）、肝母细胞瘤（HB）以及肝细胞癌和胆管细胞癌混合型（cHCC-CCA）。最近的研究表明，不同类型的肝癌中癌症干细胞（CSC）的特性存在差异。肝癌干细胞（LCSCs），也称为肝肿瘤起始细胞，被认为是肿瘤起始和转移的驱动因素。许多机制和因素，如线粒体自噬、线粒体动力学、表观遗传修饰、肿瘤微环境和肿瘤可塑性，都参与了肝癌中癌症干性的调控。在这篇综述中，我们分析了不同类型肝癌中的癌症干性。此外，我们进一步评估了 LCSCs 癌症干性维持的机制，并讨论了有望根除 LCSCs 的治疗方法。
