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亲水涂层导尿管对膀胱功能障碍患者间歇性导尿致尿道创伤、微创伤和不良事件的影响：系统评价和荟萃分析。

Effects of hydrophilic coated catheters on urethral trauma, microtrauma and adverse events with intermittent catheterization in patients with bladder dysfunction: a systematic review and meta-analysis.

机构信息

West China School of Nursing, Sichuan University/West China Hospital, Sichuan University, Guoxue Xiang #37, Chengdu, 610041, Sichuan, China.

West China Hospital, Sichuan University, Sichuan, 61004, China.

出版信息

Int Urol Nephrol. 2022 Jul;54(7):1461-1470. doi: 10.1007/s11255-022-03172-x. Epub 2022 Apr 21.

DOI:10.1007/s11255-022-03172-x
PMID:35449382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9184422/
Abstract

BACKGROUND

Hydrophilic coated catheters are recommended to reduce the side effects of intermittent catheterization (IC) in patients with bladder dysfunction. However, there is lack of Level one evidence to support the use of this intervention.

SEARCH METHODS

Several electronic databases were systematically searched to evaluate complication incidences for hydrophilic coated (HC) and non-hydrophilic catheters (NHC).

RESULTS

Twelve studies were eligible for inclusion in the review. The meta-analyses exploring microscopic hematuria frequencies (RR = 0.69; 95% CI 0.52-0.90) and urethral stricture frequencies (RR = 0.28; 95% CI 0.13-0.60) showed a lower risk ratio associated with HC in comparison to NHC, whereas gross hematuria was no statistically significant difference in two groups. Subgroup analyses of gross hematuria which was grouped according to "catheterization frequency", "single/multiple catheterization" and "self/other catheterization" were performed and the values of combined RR were also no statistically significant difference.

CONCLUSIONS

Compared with non-hydrophilic catheters, the hydrophilic coated catheters have positive significance in reducing the incidence of urethral microtrauma and the urethral stricture. However, more studies are warranted for evaluating effects of hydrophilic coated catheters on the incidence of gross hematuria.

摘要

背景

亲水涂层导尿管被推荐用于减少膀胱功能障碍患者间歇性导尿的副作用。然而，缺乏一级证据支持这种干预措施的使用。

检索方法

系统地检索了几个电子数据库，以评估亲水涂层（HC）和非亲水导管（NHC）的并发症发生率。

结果

有 12 项研究符合纳入标准。荟萃分析显示，与 NHC 相比，HC 组显微镜下血尿的发生频率（RR=0.69；95%CI 0.52-0.90）和尿道狭窄的发生频率（RR=0.28；95%CI 0.13-0.60）较低，而两组间肉眼血尿无统计学差异。对根据“导尿频率”、“单次/多次导尿”和“自我/他人导尿”分组的肉眼血尿进行亚组分析，合并 RR 值也无统计学差异。

结论

与非亲水导管相比，亲水涂层导尿管在减少尿道微创伤和尿道狭窄的发生率方面具有积极意义。然而，还需要更多的研究来评估亲水涂层导尿管对肉眼血尿发生率的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/2d2b48a8e4c4/11255_2022_3172_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/1a1cd9d6b59b/11255_2022_3172_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/b2add5a71f3b/11255_2022_3172_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/a4851446d9a4/11255_2022_3172_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/be3671c21bc2/11255_2022_3172_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/478ad844b372/11255_2022_3172_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/2d2b48a8e4c4/11255_2022_3172_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/1a1cd9d6b59b/11255_2022_3172_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/b2add5a71f3b/11255_2022_3172_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/a4851446d9a4/11255_2022_3172_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/be3671c21bc2/11255_2022_3172_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/478ad844b372/11255_2022_3172_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e18/9184422/2d2b48a8e4c4/11255_2022_3172_Fig6_HTML.jpg

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