Oberoi Mansi, Perinkulam Sathyanarayanan Swaminathan, Akther Jacky, Tantoush Hamza
Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.
Pathology, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.
Cureus. 2022 Mar 16;14(3):e23232. doi: 10.7759/cureus.23232. eCollection 2022 Mar.
There has been an observance of increased occurrence of malignant lymphomas in patients with rheumatoid arthritis (RA). The increased risk of lymphoproliferative disorders has been linked to the severity of RA disease activity, the use of disease-modifying agents like methotrexate and certain genetic links between RA and lymphomas. This article outlines the case of an 88-year-old gentleman with a 13-year history of seropositive rheumatoid arthritis on methotrexate who presented with ankle pain and was subsequently found to have diffuse large B-cell lymphoma on further workup.
类风湿关节炎（RA）患者中恶性淋巴瘤的发生率有所增加。淋巴增殖性疾病风险的增加与RA疾病活动的严重程度、甲氨蝶呤等改善病情药物的使用以及RA与淋巴瘤之间的某些基因联系有关。本文概述了一名88岁男性的病例，他有13年血清阳性类风湿关节炎病史，正在接受甲氨蝶呤治疗，因踝关节疼痛就诊，进一步检查后发现患有弥漫性大B细胞淋巴瘤。
