Cardiac Complications of Myeloproliferative Disorders.

Thrombosis occurs in about one-third of cases of myeloproliferative disorders, contributing to a mortality rate of 15% to 40%. It may involve the arteries and veins, including hepatic, mesenteric, and portal, and even the cardiac circulation. Cardiovascular involvement varies from 4% to 21%. Acute ischemic coronary artery disease may be at the root of presenting symptoms of such disorders, particularly in younger patients. The authors review the literature linking cardiac diseases with myeloproliferative disorders and advise a high degree of suspicion for an underlying myeloproliferative disorder in a young patient presenting with cardiac disease with no known risk factors.