Department of Reproductive Medicine, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, 20 Yuhuangding East Road, Yantai 264000, China.
Central Laboratory, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, 20 Yuhuangding East Road, Yantai 264000, China.
J Healthc Eng. 2022 Apr 11;2022:9748041. doi: 10.1155/2022/9748041. eCollection 2022.
Clinical cases of a polycystic ovarian syndrome (PCOS) have prolonged subclinical inflammation. Hysteroscopy has revealed worsened chronic endometritis (CE), particularly endometrial diffuse hyperemia, in PCOS patients. However, the possible relationships between PCOS and CE remain largely unexplored.
This retrospective-based investigation was conducted on 3336 infertile patients. The PCOS group consisted of 508 patients, while the non-POCS group consisted of 2828 individuals with normal ovarian function. Their clinical features and CE prevalence diagnosed with hysteroscopy were compared. The risk factors affecting the incidence of diffuse endometrial hyperemia were analyzed by binary logistic regression.
The PCOS cohort and the non-PCOS cohort showed marked variations in age, body mass index (BMI), infertility (primary, secondary), basal hormone level (bFSH, bLH, bT, and PRL), anti-Müllerian hormone (AMH), and CA125 ( < 0.05). The prevalence of CE in PCOS women was 41.73% (212/508), markedly higher than the 28.50% in the non-PCOS cohort (806/2828). Variations within diffuse endometrial hyperemia prevalence were especially marked ( < 0.05). Furthermore, we found that the variables of BMI, bLH, bT, and AMH correlated with diffuse endometrial hyperemia.
CE prevalence was elevated in clinical cases of infertility associated with PCOS, and diffuse endometrial hyperemia was prevalent, as indicated by hysteroscopy. Furthermore, increased BMI, bLH, bT, and AMH levels all contribute to the risk of diffuse endometrial hyperemia.
多囊卵巢综合征（PCOS）的临床病例存在长期亚临床炎症。宫腔镜检查显示 PCOS 患者的慢性子宫内膜炎（CE）恶化，尤其是子宫内膜弥漫性充血。然而，PCOS 和 CE 之间的可能关系在很大程度上仍未得到探索。
本回顾性研究纳入了 3336 名不孕患者。PCOS 组包括 508 例患者，而非 PCOS 组包括 2828 例卵巢功能正常的个体。比较了两组患者的临床特征和宫腔镜诊断的 CE 患病率。采用二项逻辑回归分析影响弥漫性子宫内膜充血发生率的危险因素。
PCOS 组和非 PCOS 组在年龄、体重指数（BMI）、不孕（原发、继发）、基础激素水平（bFSH、bLH、bT 和 PRL）、抗苗勒管激素（AMH）和 CA125 方面存在显著差异（<0.05）。PCOS 组中 CE 的患病率为 41.73%（212/508），明显高于非 PCOS 组的 28.50%（806/2828）。弥漫性子宫内膜充血患病率的差异尤其显著（<0.05）。此外，我们发现 BMI、bLH、bT 和 AMH 等变量与弥漫性子宫内膜充血相关。
与 PCOS 相关的不孕临床病例中 CE 的患病率升高，宫腔镜检查显示弥漫性子宫内膜充血较为常见。此外，BMI、bLH、bT 和 AMH 水平的升高均增加了弥漫性子宫内膜充血的风险。
