Department of Ultrasound, Affiliated Heji Hospital of Shanxi Changzhi Medical College, Changzhi City 046000, Shanxi Province, China.
Department of Gynecology, Affiliated Heji Hospital of Shanxi Changzhi Medical College, Changzhi City 046000, Shanxi Province, China.
J Healthc Eng. 2022 Apr 12;2022:4880874. doi: 10.1155/2022/4880874. eCollection 2022.
To explore the application value of real-time ultrasonic elastograph (USE) with serum human epididymis protein 4 HE4, interleukin-33 (IL-33), and carbohydrate antigen 153 (CA153) in the diagnosis of early cervical cancer.
A total of 120 cervical cancer patients treated in our hospital (06, 2019-06, 2021) and meeting the study criteria were screened and divided into the benign group (BG, = 70) and malignant group (MG, = 50) according to their final diagnostic results, and healthy females who received physical examination in our hospital in the same period were selected as the control group (CG, = 60). Patients in the three groups received real-time USE and detection of serum HE4, IL-33, and CA153 so as to analyze the diagnostic value of single examination and combined examination in diagnosing early cervical cancer.
The patients' real-time USE score, , , and elastic fibers were significantly higher in the MG than those in the BG ( < 0.05), and the patients' real-time USE , stroma ratio and collagen fibers were significantly lower in the MG than those in the BG ( < 0.05); the HE4, IL-33, and CA153 levels were obviously higher in the MG than those in the BG ( < 0.05) and were significantly higher in the BG than those in the CG ( < 0.05); the positive detection rate of combining real-time USE with serum HE4, IL-33, and CA153 was higher than that of single examination, and the diagnostic accuracy rate, sensitivity, specificity, positive predictive value, and negative predictive value of the combined examination were significantly higher than those of single examination ( < 0.05); according to the diagnostic efficacy of single examination and combined examination in diagnosing early cervical cancer by ROC curve, it was combined diagnosis > real-time USE > HE4 > CA153 > IL-33.
Combined examination of real-time USE and serum HE4, IL-33, and CA153 has higher diagnostic value in diagnosing early cervical cancer, which can obviously improve the diagnostic accuracy rate of cervical cancer.
探讨实时超声弹性成像（USE）联合血清人附睾蛋白 4（HE4）、白细胞介素-33（IL-33）、糖类抗原 153（CA153）在早期宫颈癌诊断中的应用价值。
筛选我院收治的 120 例宫颈癌患者（2019 年 6 月至 2021 年 6 月），并根据最终诊断结果分为良性组（BG，n=70）和恶性组（MG，n=50），同时选取同期我院体检的健康女性为对照组（CG，n=60）。三组患者均接受实时 USE 检查和血清 HE4、IL-33、CA153 检测，分析单项检查及联合检查诊断早期宫颈癌的价值。
MG 组患者实时 USE 评分、 、弹性纤维评分均显著高于 BG 组（ < 0.05），实时 USE 评分、间质比、胶原纤维评分均显著低于 BG 组（ < 0.05）；MG 组患者 HE4、IL-33、CA153 水平均显著高于 BG 组（ < 0.05），且均显著高于 CG 组（ < 0.05）；联合实时 USE 与血清 HE4、IL-33、CA153 检测的阳性检出率高于单项检查，且联合检查的诊断准确率、敏感度、特异度、阳性预测值、阴性预测值均显著高于单项检查（ < 0.05）；根据 ROC 曲线分析，单项检查和联合检查诊断早期宫颈癌的诊断效能，联合诊断>实时 USE>HE4>CA153>IL-33。
实时 USE 联合血清 HE4、IL-33、CA153 检查对早期宫颈癌的诊断具有较高的诊断价值，可明显提高宫颈癌的诊断准确率。
