日本类风湿关节炎患者中rs12702634与间质性肺疾病的无关联
Lack of Association of rs12702634 in With Interstitial Lung Diseases in Japanese Rheumatoid Arthritis Patients.
作者信息
Higuchi Takashi, Oka Shomi, Furukawa Hiroshi, Shimada Kota, Tohma Shigeto
机构信息
Department of Clinical Research, National Hospital Organization Tokyo National Hospital, Kiyose, Japan.
Department of Nephrology, Ushiku Aiwa General Hospital, Ushiku, Japan.
出版信息
Biomark Insights. 2022 Apr 15;17:11772719221091758. doi: 10.1177/11772719221091758. eCollection 2022.
BACKGROUND
Rheumatoid arthritis (RA) is occasionally complicated with interstitial lung disease (ILD). A recent genome-wide association study of ILD in RA reported an association with the polymorphism rs12702634 in . We conducted an association study of this variant with ILD in Japanese RA patients to replicate this association.
METHODS
Genotyping of rs12702634 was performed in 175 RA with ILD and 411 RA without chronic lung disease.
RESULTS
No association was detected for rs12702634 with ILD in RA ( = .6369, odds ratio [OR] 1.13, 95% confidence interval [CI] 0.72-1.78). Meta-analysis of these data combined with the data from the recent report showed no significant association ( = .0996, OR 1.52, 95% CI 0.92-2.49).
CONCLUSIONS
The present study demonstrated no association of rs12702634 with ILD in RA, suggesting the heterogeneity of the disease.
背景
类风湿关节炎（RA）偶尔会并发间质性肺疾病（ILD）。最近一项关于RA中ILD的全基因组关联研究报告称，其与某基因中的单核苷酸多态性rs12702634存在关联。我们在日本RA患者中开展了该变异与ILD的关联研究，以重复这一关联。
方法
对175例患有ILD的RA患者和411例无慢性肺部疾病的RA患者进行了rs12702634基因分型。
结果
在RA患者中，未检测到rs12702634与ILD之间存在关联（P = 0.6369，优势比[OR]为1.13，95%置信区间[CI]为0.72 - 1.78）。将这些数据与近期报告中的数据进行荟萃分析，结果显示无显著关联（P = 0.0996，OR为1.52，95% CI为0.92 - 2.49）。
结论
本研究表明，在RA患者中，rs12702634与ILD无关联，提示该疾病具有异质性。
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