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[羊痘疮:初次感染8个月后再次感染。结合病例对文献的综述]

[Orf: recontamination 8 months after the original infection. Review of the literature apropos of a case].

作者信息

Gourreau J M, Mornet M, Gressin R, Fraisse J C, Gourvil J, Lesouple C

出版信息

Ann Dermatol Venereol. 1986;113(11):1065-76.

PMID:3545022
Abstract

Frequent in France among domesticated sheep and goats, contagious pustular dermatitis of the sheep is called Orf when it occurs in man. The authors present a case of recontamination in a woman farmer of the Cher department (Central France), who had been bottle-feeding lambs affected with the zoonosis. This 71-year old woman developed papules, then papulopustules on the ulnar aspect of her hands and wrists (fig. 1). Within a few days, these lesions were 1.5 to 2 cm in diameter and surrounded with a severe inflammatory reaction. Two weeks later, the pustules became encrusted. Electron microscopy of a fragment of lesion demonstrated the virus. Cure was observed after 3 weeks. Eight months later, however, lesions identical with the previous ones appeared on the 4th finger and on the median aspect of the right wrist, corresponding to excoriations caused by nibbling from the lambs. The eruption was accompanied with fever which persisted for one month. In this patient's farm, the disease was present for the first time and affected only 2-month old lambs in the form of numerous papulo-pustules located on the lips and later covered by hard and thick scabs. These lesions were also found on the tongue and palate of some animals (fig. 5), preventing them from taking any food. Vaccination resulted in rapid and dramatic regression of the enzootie. From a more general point of view, the clinical features and epidemiology of the disease are described comparatively in animals and man. The differential diagnosis is dealt with at the end of the article. The literature on the subject is reviewed (151 references).

摘要

绵羊传染性脓疱性皮炎在法国的家养绵羊和山羊中很常见,当它发生在人类身上时被称为羊痘。作者介绍了法国中部谢尔省一位女农民再次感染的病例,她曾用奶瓶喂养感染人畜共患病的羔羊。这位71岁的女性双手和手腕尺侧出现丘疹,随后发展为丘疱疹(图1)。几天内,这些病变直径达1.5至2厘米,并伴有严重的炎症反应。两周后,脓疱结痂。对病变组织碎片进行电子显微镜检查发现了病毒。3周后观察到病情痊愈。然而,8个月后,与之前相同的病变出现在右手无名指和右腕正中,对应于羔羊啃咬造成的擦伤处。皮疹伴有持续一个月的发热。在该患者的农场中,该病首次出现,仅感染2月龄的羔羊,表现为唇部出现大量丘疱疹,随后被坚硬、厚实的痂皮覆盖。在一些动物的舌头和上腭也发现了这些病变(图5),导致它们无法进食。接种疫苗后动物疫病迅速显著消退。从更普遍的角度来看,对该病在动物和人类中的临床特征及流行病学进行了比较描述。文章结尾讨论了鉴别诊断。对该主题的文献进行了综述(151篇参考文献)。

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