Patil P Harshali, Pereira Treville, Winnier J Jasmin, Shetty J Subraj
Department of Pedodontics and Preventive Dentistry, D.Y. Patil University School of Dentistry, Navi Mumbai, Maharashtra, India.
Department of Oral pathology and Microbiology, D.Y. Patil University School of Dentistry, Navi Mumbai, Maharashtra, India.
J Oral Maxillofac Pathol. 2022 Feb;26(Suppl 1):S80-S83. doi: 10.4103/jomfp.jomfp_363_20. Epub 2022 Feb 28.
Inflammatory myofibroblastic tumor (IMT) of the oral cavity is an extremely rare finding. The etiology and pathogenesis of IMT is controversial and unclear. The tumor requires complete surgical excision and continuous monitoring of clinical consequences. The present article describes the clinical, histological, operative and immunohistochemical features of a case of IMT in the mandibular retromolar region of an 8-year-old male. Histologically, the lesion shows myofibroblastic spindle cell proliferations with infiltrative margins in an inflammatory background. Immunohistochemically, the myofibroblastic spindle cells in the present case were positive for α-smooth muscle actin and CD68 due to which the diagnosis of IMT was confirmed.
口腔炎性肌纤维母细胞瘤(IMT)极为罕见。IMT的病因和发病机制存在争议且尚不明确。该肿瘤需要完整手术切除并持续监测临床后果。本文描述了一名8岁男性下颌磨牙后区IMT病例的临床、组织学、手术及免疫组化特征。组织学上,病变显示在炎症背景下肌纤维母细胞梭形细胞增生,边界浸润。免疫组化方面,本例中的肌纤维母细胞梭形细胞α-平滑肌肌动蛋白和CD68呈阳性,据此确诊为IMT。