Liu Feng, Qin Yanchao, Zhang Zhiwei, Li Mengru, Feng Bowei, Ding Wei, Dong Shubin
Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
First Clinical Medical School, Shanxi Medical University, Taiyuan, Shanxi, China.
PeerJ. 2025 Apr 18;13:e19315. doi: 10.7717/peerj.19315. eCollection 2025.
This study aimed to investigate the clinical features, treatment methods, and prognosis of head and neck inflammatory myofibroblastic tumor (HNIMT).
A retrospective analysis was conducted using the clinical data of 12 HNIMT patients who were admitted to Shanxi Cancer Hospital between January 2016 and December 2023. This analysis focused on their clinical manifestations, pathological characteristics, treatment strategies, and prognosis.
Among the 12 cases analyzed, four involved inflammatory myofibroblastic tumors (IMT) located in the nasal sinuses or nasopharynx, with symptoms including nasal congestion, rhinorrhea, and maxillofacial swelling. Two cases each in the salivary glands and oral cavity presented as localized, painless masses. One right cervical IMT case also presented as a painless lump. Two laryngeal IMT cases had hoarseness, and one subglottic endotracheal IMT case showed inspiratory dyspnea. All patients received surgery, with postoperative pathology confirming IMT. During follow-up, four cases recurred. Finally, nine patients were disease-free, two survived with disease, and one died.
HNIMT is a rare, low-grade malignant or borderline tumor that is generally associated with a favorable prognosis. Accurate diagnosis relies on pathological examination, and surgical resection remains the primary treatment for HNIMT. The need for adjuvant therapy following surgery should be determined by clinicians based on tumor location, surgical approach, and the presence of high-risk factors.
本研究旨在探讨头颈部炎性肌纤维母细胞瘤（HNIMT）的临床特征、治疗方法及预后。
回顾性分析2016年1月至2023年12月期间入住山西医科大学附属肿瘤医院的12例HNIMT患者的临床资料，重点分析其临床表现、病理特征、治疗策略及预后。
在分析的12例病例中，4例炎性肌纤维母细胞瘤（IMT）位于鼻窦或鼻咽部，症状包括鼻塞、流涕和颌面肿胀。唾液腺和口腔各有2例表现为局限性无痛肿块。1例右侧颈部IMT病例也表现为无痛性肿块。2例喉部IMT病例有声音嘶哑，1例声门下气管内IMT病例表现为吸气性呼吸困难。所有患者均接受了手术，术后病理证实为IMT。随访期间，4例复发。最后，9例患者无疾病生存，2例带瘤生存，1例死亡。
HNIMT是一种罕见的低度恶性或交界性肿瘤，总体预后良好。准确诊断依赖于病理检查，手术切除仍是HNIMT的主要治疗方法。术后是否需要辅助治疗应由临床医生根据肿瘤位置、手术方式及高危因素的存在情况来决定。
