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甲状旁腺功能亢进的棕色瘤伴多发病灶。

Brown tumor of hyperparathyroidism with multiple lesions.

作者信息

Majumdar Sumit, Uppala Divya, Kotina Sreekanth, Alekhya Bandi

机构信息

Department of Oral Pathology and Microbiology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India.

出版信息

J Oral Maxillofac Pathol. 2022 Feb;26(Suppl 1):S111-S115. doi: 10.4103/jomfp.jomfp_409_20. Epub 2022 Feb 28.

DOI:10.4103/jomfp.jomfp_409_20
PMID:35450253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9017852/
Abstract

Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone (PTH) on bone tissue in some patients with hyperparathyroidism. Browns tumor is a syndrome associated with an increase in PTH levels by parathyroid glands resulting in hypercalcemia. In the present case report, a 44-year-old female patient presented with a rare case of brown tumor with multiple lesions in the head-and-neck region. The recent advance in various diagnostic and biochemical tests helps in early diagnosis of hyperparathyroidism cases. The dentist should be aware of oral manifestations associated with this type of systemic disease.

摘要

棕色瘤是一种罕见的局灶性巨细胞病变,是一些甲状旁腺功能亢进患者甲状旁腺激素(PTH)作用于骨组织的直接结果。棕色瘤是一种与甲状旁腺导致PTH水平升高并引起高钙血症相关的综合征。在本病例报告中,一名44岁女性患者出现了罕见的头颈部多发棕色瘤病例。各种诊断和生化检查的最新进展有助于甲状旁腺功能亢进病例的早期诊断。牙医应了解与这类全身性疾病相关的口腔表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/102abb245f89/JOMFP-26-111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/c59654827090/JOMFP-26-111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/29c501386956/JOMFP-26-111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/e0bbaa92ee39/JOMFP-26-111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/affbfe0a8750/JOMFP-26-111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/102abb245f89/JOMFP-26-111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/c59654827090/JOMFP-26-111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/29c501386956/JOMFP-26-111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/e0bbaa92ee39/JOMFP-26-111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/affbfe0a8750/JOMFP-26-111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/9017852/102abb245f89/JOMFP-26-111-g005.jpg

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本文引用的文献

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Giant Cell Lesions Associated with Primary Hyperparathyroidism.与原发性甲状旁腺功能亢进相关的巨细胞病变
J Maxillofac Oral Surg. 2015 Dec;14(4):930-4. doi: 10.1007/s12663-014-0719-4. Epub 2014 Nov 8.
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Primary hyperparathyroidism in India: A cocktail of contemporary and classical presentations: Lesson from 47 cases.印度原发性甲状旁腺功能亢进症:当代与经典表现的混合体:47例病例的经验教训
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S209-11. doi: 10.4103/2230-8210.119574.
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Brown tumor in mandible as a first sign of vitamin D deficiency: A rare case report and review.
下颌骨棕色瘤作为维生素D缺乏的首发症状:1例罕见病例报告及文献复习
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Int J Endocrinol. 2011;2011:921814. doi: 10.1155/2011/921814. Epub 2011 May 26.
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Primary hyperparathyroidism: an overview.原发性甲状旁腺功能亢进症:概述。
Int J Endocrinol. 2011;2011:251410. doi: 10.1155/2011/251410. Epub 2011 Jun 2.
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Brown tumour of the maxilla and mandible: a rare complication of tertiary hyperparathyroidism.上颌骨和下颌骨棕色瘤:三发性甲状旁腺功能亢进的罕见并发症。
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Mutations in SH3BP2, the cherubism gene, were not detected in central or peripheral giant cell tumours of the jaw.在颌骨的中央或外周巨细胞肿瘤中未检测到天使综合征基因SH3BP2的突变。
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