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Pharmacol Ther. 2021 Dec;228:107916. doi: 10.1016/j.pharmthera.2021.107916. Epub 2021 Jun 23.
2
Engineering of stepwise-targeting chitosan oligosaccharide conjugate for the treatment of acute kidney injury.逐步靶向壳聚糖寡糖缀合物的工程化用于治疗急性肾损伤。
Carbohydr Polym. 2021 Mar 15;256:117556. doi: 10.1016/j.carbpol.2020.117556. Epub 2020 Dec 31.
3
Gallic Acid-Laminarin Conjugate Is a Better Antioxidant than Sulfated or Carboxylated Laminarin.没食子酸-海带多糖缀合物是比硫酸化或羧基化海带多糖更好的抗氧化剂。
Antioxidants (Basel). 2020 Nov 27;9(12):1192. doi: 10.3390/antiox9121192.
4
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Drug Des Devel Ther. 2020 Nov 2;14:4695-4701. doi: 10.2147/DDDT.S278342. eCollection 2020.
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Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury.用于解决缺血再灌注损伤的活性氧（ROS）响应性纳米药物
Front Chem. 2020 Aug 21;8:732. doi: 10.3389/fchem.2020.00732. eCollection 2020.
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Curcumin: an inflammasome silencer.姜黄素：一种炎症小体沉默剂。
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The role of antioxidants in the chemistry of oxidative stress: A review.抗氧化剂在氧化应激化学中的作用：综述
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一种用于急性肾损伤的逐步靶向姜黄素衍生物，Ser@TPP@CUR。

A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury.

作者信息

Yan Xia, Tan Xue-Ying, Li Yi-Xuan, Wang Hong-Bo, Jin Jian-Bo, Mao Ying-Rui, Hu Jing-Bo, Wu Ling-Hui

机构信息

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.

College of Pharmacy, Zhejiang Pharmaceutical College, Ningbo 315100, China.

出版信息

ACS Med Chem Lett. 2022 Mar 8;13(4):554-559. doi: 10.1021/acsmedchemlett.1c00585. eCollection 2022 Apr 14.

DOI:10.1021/acsmedchemlett.1c00585
PMID:35450367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9014501/
Abstract

Based on the pathological mechanisms of acute kidney injury (AKI), a stepwise targeting curcumin derivative, Ser@TPP@CUR, was developed in this study. Ser@TPP@CUR can be specifically internalized by renal tubular epithelial cells via KIM-1 receptor-mediated endocytosis and then actively distributed in mitochondria under the effect of TPP, a mitochondrial targeting molecule. Both in vitro and in vivo results showed that Ser@TPP@CUR effectively ameliorated injured renal tubular epithelial cells and improved renal functions of AKI mice.

摘要

基于急性肾损伤（AKI）的病理机制，本研究开发了一种逐步靶向的姜黄素衍生物Ser@TPP@CUR。Ser@TPP@CUR可通过KIM-1受体介导的内吞作用被肾小管上皮细胞特异性内化，然后在线粒体靶向分子TPP的作用下主动分布于线粒体中。体外和体内实验结果均表明，Ser@TPP@CUR能有效改善受损的肾小管上皮细胞，并改善AKI小鼠的肾功能。