University Clinic of Cardiology, Skopje, RN Macedonia.
Ss. Cyril and Methodius University in Skopje, Faculty of Medicine, RN Macedonia.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2022 Apr 22;43(1):49-55. doi: 10.2478/prilozi-2022-0005.
Vaccine-induced thrombotic thrombocytopenia (VITT) is a condition similar to heparin-induced thrombocytopenia (HIT), but it is associated with prior administration of COVID-19 vaccines without prior exposure to heparin. The incidence of VITT is not certain, but it appears to be extremely rare. Reports of unusual and severe thrombotic events, including cerebral and splanchnic venous thrombosis and other autoimmune adverse reactions, such as immune thrombocytopenia or thrombotic microangiopathies in connection with some of the SARS-CoV-2 vaccines, have caused a great deal of concern within the population and the medical community. We would like to present 4 clinical cases of VITT, hospitalized and treated in intensive care unit (ICU) of University clinic of cardiology in Skopje.
疫苗诱导的血栓性血小板减少症（VITT）与肝素诱导的血小板减少症（HIT）相似，但与先前接种 COVID-19 疫苗而无先前接触肝素有关。VITT 的发病率尚不确定，但似乎极为罕见。一些 SARS-CoV-2 疫苗与一些不常见和严重的血栓事件有关，包括脑和内脏静脉血栓形成以及其他自身免疫不良反应，如免疫性血小板减少症或血栓性微血管病，引起了人群和医学界的极大关注。我们将介绍 4 例 VITT 临床病例，这些病例在斯科普里大学心脏病学临床研究所的重症监护病房（ICU）住院和治疗。
