University Clinic of Psychiatry, Faculty of Medicine, University "Ss.Cyril and Methodius", Skopje, North Macedonia.
University Clinic of Endocrinology, Faculty of Medicine, University "Ss.Cyril and Methodius", Skopje, North Macedonia.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2022 Apr 22;43(1):29-39. doi: 10.2478/prilozi-2022-0003.
: Evidence for disturbances in HPA activation and abnormal HPA regulatory mechanisms in schizophrenia is accumulating. : To compare serum levels of cortisol, DHEA-S and their ratio between patients with schizophrenia and healthy controls and among patients before and after treatment with different types of antipsychotics. : In this clinical prospective study, 60 patients with schizophrenia and 40 healthy age and sex matched control subjects were included. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. Serum levels of cortisol, DHEA-S and their ratio were measured at baseline in all participants and after 3 and 6 weeks, respectively, of the antipsychotic treatment with different types of antipsychotics in patients with schizophrenia. : Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels in comparison to the control group. There was no significant difference in serum levels of cortisol, DHEA-S and their ratio between patients treated with different types of antipsychotics (typical/atypical). Serum levels of the analyzed hormones significantly reduce during the 6-week period of examination in both subgroups treated with different types of antipsychotics. : Elevated serum cortisol and DHEA-S in schizophrenic patients might be associated with their role in the pathophysiology of the disorder. There is no significant difference in serum levels of cortisol, DHEA-S and their ratio among the patients treated with different types of antipsychotics.
：精神分裂症患者的 HPA 激活和异常 HPA 调节机制紊乱的证据正在积累。：比较精神分裂症患者与健康对照组之间以及不同类型抗精神病药物治疗前后的血清皮质醇、DHEA-S 及其比值。：在这项临床前瞻性研究中，纳入了 60 名精神分裂症患者和 40 名年龄和性别匹配的健康对照者。所有患者均经历了疾病的急性恶化（PANSS：P1 和 P3≥4）。采用阳性和阴性症状量表对患者进行临床评估。使用社会人口统计学和临床数据收集问卷。在所有参与者中，在基线时测量血清皮质醇、DHEA-S 及其比值，并分别在精神分裂症患者接受不同类型抗精神病药物治疗的 3 周和 6 周后测量。：与对照组相比，精神分裂症患者的血清皮质醇和 DHEA-S 水平显著升高。不同类型抗精神病药物治疗的患者之间，血清皮质醇、DHEA-S 及其比值无显著差异（典型/非典型）。在接受不同类型抗精神病药物治疗的两个亚组中，在 6 周的检查期间，分析的激素血清水平均显著降低。：精神分裂症患者血清皮质醇和 DHEA-S 升高可能与其在疾病病理生理学中的作用有关。不同类型抗精神病药物治疗的患者之间，血清皮质醇、DHEA-S 及其比值无显著差异。
