既往新冠病毒感染对冠状动脉微血管功能障碍的影响。

The effect of prior COVID-19 infection on coronary microvascular dysfunction.

作者信息

Bilge Önder, Çap Murat, Kepenek Ferat, Erdogan Emrah, Tatlı İsmail, Öztürk Cansu, Taştan Ercan, Gündoğan Cihan, Işık Ferhat, Okşul Metin, Oktay Mesut, Akın Halil, Burak Cengiz, Karahan Mehmet Zülküf, Kömek Halil, Tanboğa İbrahim Halil

机构信息

Department of Cardiology, University of Health Sciences Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakır, Turkey.

Department of Nuclear Medicine, University of Health Sciences Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakır, Turkey.

出版信息

Acta Cardiol. 2022 Oct;77(8):693-698. doi: 10.1080/00015385.2022.2067641. Epub 2022 Apr 22.

DOI:10.1080/00015385.2022.2067641

PMID:35451344

Abstract

BACKGROUND

Thrombolysis in Myocardial Infarction Frame Count (TFC) is an index that provides a quantitative evaluation of coronary microvascular dysfunction. In this study, we aimed to examine the effect of COVID-19 infection on TFC in patients admitted with chest pain and dyspnoea after COVID-19 disease and had abnormal findings in myocardial perfusion scintigraphy.

METHODS

For this single-center retrospective study, patients with and without a history of COVID-19 who were underwent coronary angiography for abnormal findings in myocardial perfusion scintigraphy between January 1, 2021 and June 30, 2021 were analysed. Patients were divided into two groups as patients with COVİD-19 history and those without. After exclusion criteria, patients with adequate angiographic monitoring and data were included in the study.

RESULTS

A total of 210 patients, 48 with a history of COVID-19, were included in the study. The mean age was ±55 10 years, and 122 (58%) patients were women. In patients with a history of COVID-19, TFC was significantly higher in the LAD ( < 0.001) and LCx ( < 0.001) arteries and RCA TFC ( = 0.223) was similar in both groups. In the linear mix model, male gender ( = 2.38, 95% CI = 1.26-3.51, < 0.001) and history of COVID-19 ( = 1.51, 95% CI = 0.49-2.53, = 0.004) were significantly associated with TFC.

CONCLUSION

TFC may be elevated due to coronary microvascular dysfunction in patients with a history of COVID-19.

摘要

背景

心肌梗死溶栓帧数（TFC）是一项用于定量评估冠状动脉微血管功能障碍的指标。在本研究中，我们旨在探讨新型冠状病毒肺炎（COVID-19）感染对COVID-19疾病后因胸痛和呼吸困难入院且心肌灌注显像有异常发现的患者TFC的影响。

方法

对于这项单中心回顾性研究，分析了2021年1月1日至2021年6月30日期间因心肌灌注显像异常而接受冠状动脉造影的有或无COVID-19病史的患者。患者分为有COVID-19病史组和无COVID-19病史组。经过排除标准后，具有充分血管造影监测和数据的患者被纳入研究。

结果

共有210例患者纳入研究，其中48例有COVID-19病史。平均年龄为±55 10岁，122例（58%）为女性。有COVID-19病史的患者，左前降支（LAD）（<0.001）和左旋支（LCx）（<0.001）动脉的TFC显著更高，两组右冠状动脉（RCA）的TFC相似（=0.223）。在线性混合模型中，男性（=2.38，95%可信区间=1.26 - 3.51，<0.001）和COVID-19病史（=1.51，95%可信区间=0.49 - 2.53，=0.004）与TFC显著相关。