癌症和阻塞性睡眠呼吸暂停：一项更新的荟萃分析。
Cancer and obstructive sleep apnea: An updated meta-analysis.
机构信息
Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Clinical Laboratory, The Affiliated Children Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
出版信息
Medicine (Baltimore). 2022 Mar 11;101(10):e28930. doi: 10.1097/MD.0000000000028930.
OBJECTIVE
The relationship between cancers and obstructive sleep apnea (OSA) has been discussed for decades. However, the previous meta-analysis led to opposite conclusions. To further investigate this controversial issue, we performed this systematic review and meta-analysis update.
METHODS
PubMed, Embase, and the Cochrane Library were systematically searched and studies on "cancer and OSA" were all included. Two reviewers independently searched articles, extracted data, and assessed the quality of included studies. Moreover, the overall incidence of cancer and OSA in corresponding populations was calculated.
RESULTS
Of the 1434 titles identified, 22 articles involving more than 32.1 million patients were included in this meta-analysis. An overall incidence of OSA positive individuals in cancer was 46 (95%CI, 27-67)%, and the prevalence of cancers in OSA patients reached 1.53 (95%CI, 1.01-2.31) times higher than non-OSA individuals.
CONCLUSION
This meta-analysis indicated that there was a high prevalence of OSA in cancer patients, and individuals with OSA were more likely to develop tumors, and the incidence was related to the severity of OSA.
目的
癌症与阻塞性睡眠呼吸暂停（OSA）之间的关系已被讨论了数十年。然而，之前的荟萃分析得出了相反的结论。为了进一步研究这一争议性问题，我们进行了这项系统评价和荟萃分析更新。
方法
系统检索了 PubMed、Embase 和 Cochrane Library 中的文献，并纳入了所有关于“癌症和 OSA”的研究。两位评审员独立检索文章、提取数据并评估纳入研究的质量。此外，还计算了相应人群中癌症和 OSA 的总体发生率。
结果
在 1434 个标题中，有 22 篇文章纳入了这项荟萃分析，涉及超过 3210 万名患者。癌症患者中 OSA 阳性个体的总体发生率为 46%（95%CI，27%-67%），OSA 患者中癌症的患病率比非 OSA 个体高 1.53 倍（95%CI，1.01-2.31）。
结论
这项荟萃分析表明，癌症患者中 OSA 的患病率较高，且 OSA 个体更有可能发生肿瘤，其发生率与 OSA 的严重程度有关。
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