中药治疗糖尿病认知功能障碍的认知功能障碍的疗效和安全性比较：系统评价和贝叶斯网络荟萃分析的方案。
Comparative efficacy and safety of traditional Chinese patent medicine for cognitive dysfunction in diabetic cognitive dysfunction: A protocol for systematic review and Bayesian network meta-analysis.
机构信息
Shandong Provincial Hospital Affiliated to Shandong First Medical University, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
出版信息
Medicine (Baltimore). 2022 Mar 11;101(10):e28946. doi: 10.1097/MD.0000000000028946.
BACKGROUND
More and more studies have shown that cognitive dysfunction is one of the main complications of diabetes. The disorder of glucose and lipid metabolism seriously damages brain function and accelerates the conversion to dementia. At present, there are no drugs that can directly treat diabetic cognitive dysfunction. All drugs for the treatment of this disease achieve the purpose of treatment through strict control of blood sugar levels. This method has great limitations. Traditional Chinese patent medicines (TCPMs) work through multiple targets and multiple pathways, which can not only effectively correct the state of glucose and lipid metabolism disorders, but also significantly improve cognitive ability, but there is a lack of systematic evaluation of their effectiveness and safety. We use the method of network meta-analysis to systematically and comprehensively compare the effectiveness and safety of different Chinese patent medicines.
METHODS
We will comprehensively search the following databases, including Web of Science, PubMed, The Cochrane Library, EMBASE, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Wanfang database and China BioMedical Literature. We will include all randomized controlled trials that meet the inclusion criteria, starting from the establishment of the database until September 2021. Two researchers will independently screen the literature based on inclusion criteria. While extracting data, we also assess the risk of bias in the included studies. All the data and evidence obtained will be evaluated by the method of Bayesian network meta-analysis.
RESULTS
This study will evaluate the effectiveness and safety of various TCPMs for diabetic cognitive dysfunction.
CONCLUSION
The results of this study will provide valuable references for the clinical application of TCPMs, and assist clinicians in formulating more reasonable diagnosis and treatment strategies.
ETHICS AND DISSEMINATION
This study does not require ethical approval.
INTERNATIONAL PLATFORM OF REGISTERED SYSTEMATIC REVIEW AND METAANALYSIS PROTOCOLS REGISTRATION NUMBER
INPLASY202190008.
背景
越来越多的研究表明，认知功能障碍是糖尿病的主要并发症之一。糖、脂代谢紊乱严重损害脑功能，加速向痴呆转化。目前，尚无药物可以直接治疗糖尿病性认知功能障碍，所有治疗该疾病的药物都是通过严格控制血糖水平来达到治疗目的，这种方法存在很大的局限性。中药复方制剂（TCPMs）通过多靶点、多途径发挥作用，不仅能有效纠正糖、脂代谢紊乱状态，而且能显著改善认知能力，但缺乏对其有效性和安全性的系统评价。我们采用网络荟萃分析方法，系统全面地比较不同中药专利制剂的疗效和安全性。
方法
我们将全面检索以下数据库，包括 Web of Science、PubMed、The Cochrane Library、EMBASE、中国知网、中文科技期刊数据库、万方数据库和中国生物医学文献数据库。我们将纳入所有符合纳入标准的随机对照试验，时间从数据库建立到 2021 年 9 月。两名研究人员将根据纳入标准独立筛选文献。在提取数据的同时，我们还评估了纳入研究的偏倚风险。所有获得的数据和证据都将通过贝叶斯网络荟萃分析方法进行评估。
结果
本研究将评估各种 TCPMs 治疗糖尿病性认知功能障碍的有效性和安全性。
结论
本研究的结果将为 TCPMs 的临床应用提供有价值的参考，协助临床医生制定更合理的诊断和治疗策略。
伦理和传播
本研究不需要伦理批准。
国际注册系统评价和荟萃分析方案注册平台编号
INPLASY202190008。
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