从头基因的起源和功能：逆势而上？
The Origins and Functions of De Novo Genes: Against All Odds?
机构信息
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
出版信息
J Mol Evol. 2022 Aug;90(3-4):244-257. doi: 10.1007/s00239-022-10055-3. Epub 2022 Apr 22.
Abstract
"De novo" genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.
摘要
“从头开始”的基因是由以前非基因 DNA 进化而来的。这让我们许多人感到惊讶，因为似乎随机序列产生一个功能基因的可能性极小。这怎么可能呢？在这篇两部分的综述中，我首先总结了目前已知的少数几个具有此类信息的从头基因的起源和分子功能。然后，我推测这些例子可能告诉我们，尽管面临巨大的不利因素，从头基因是如何设法出现的。
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