钯（0）催化的芳炔环化反应：一种合成硫桥连化合物的强大策略。

Palladium(0)-catalyzed aryne annulation: a powerful strategy for the synthesis of thio-bridged compounds.

作者信息

Morja Mayur I, Chikhalia Kishor H

机构信息

Department of Chemistry, Government Science College, Vankal, Surat, Gujarat, 394350, India.

Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India.

出版信息

Mol Divers. 2023 Feb;27(1):299-311. doi: 10.1007/s11030-022-10424-6. Epub 2022 Apr 22.

DOI:10.1007/s11030-022-10424-6

PMID:35451702

Abstract

A method for the construction of various thio-bridged compounds is developed using readily available o-(trimethylsilyl)aryl triflates as a source of aryne precursor, catalyzed by simple Pd(dba)/dppe complex. This operationally simple and modular protocol allows thio-bridged compound via C(sp)-C(sp) and C(sp)-C(sp) bond formation in promising yields with a broad substrate scope. The key part is in situ generation of an aryne from o-(trimethylsilyl)aryl triflates and their subsequent intermolecular annulation.

摘要

开发了一种构建各种硫桥化合物的方法，该方法使用易于获得的邻（三甲基硅基）芳基三氟甲磺酸酯作为芳炔前体的来源，并由简单的Pd(dba)/dppe配合物催化。这种操作简单且模块化的方案能够通过C(sp)-C(sp)和C(sp)-C(sp)键的形成来制备硫桥化合物，产率可观，底物范围广泛。关键步骤是由邻（三甲基硅基）芳基三氟甲磺酸酯原位生成芳炔及其随后的分子间环化反应。