离子通透性与多烯抗生素对白色念珠菌致死作用之间的解离
Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans.
作者信息
Chen W C, Chou D L, Feingold D S
出版信息
Antimicrob Agents Chemother. 1978 Jun;13(6):914-7. doi: 10.1128/AAC.13.6.914.
Abstract
Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pores formed by the polyene antibiotics are not central to the lethal action of the drugs.
摘要
本文给出了四种多烯抗生素两性霉素B、两性霉素B甲酯盐酸盐、制霉菌素和制霉菌素甲酯盐酸盐从白色念珠菌释放钾以及杀死白色念珠菌的动力学数据。在引起钾释放而非杀死细胞方面，制霉菌素比两性霉素相对更有效。这些数据表明，多烯抗生素形成的水性通道或孔对于药物的致死作用并非关键因素。
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本文引用的文献
1
Intracellular Loss of Potassium in Candida albicans After Exposure to Polyene Antifungal Antibiotics.白色念珠菌暴露于多烯类抗真菌抗生素后细胞内钾的流失
Appl Microbiol. 1966 Nov;14(6):953-6. doi: 10.1128/am.14.6.953-956.1966.
2
The ion permeability induced in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B.多烯抗生素制霉菌素和两性霉素B在薄脂质膜中诱导产生的离子通透性。
J Gen Physiol. 1970 Jul;56(1):100-24. doi: 10.1085/jgp.56.1.100.
3
The action of polyene antibiotics on lipid bilayer membranes in the presence of several cations and anions.多烯抗生素在几种阳离子和阴离子存在的情况下对脂质双分子层膜的作用。
Biochim Biophys Acta. 1971 Aug 13;241(2):310-30. doi: 10.1016/0005-2736(71)90031-9.
4
Molecular aspects of polyene- and sterol-dependent pore formation in thin lipid membranes.薄脂质膜中多烯和甾醇依赖性孔形成的分子机制
J Gen Physiol. 1970 Mar;55(3):375-400. doi: 10.1085/jgp.55.3.375.
5
6
Permeability control in animal cells by polyenes: a possibility.多烯对动物细胞通透性的控制：一种可能性。
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7
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8
Fungal sterols and the mode of action of the polyene antibiotics.真菌甾醇与多烯抗生素的作用方式
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9
10
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