Zygmunt W A
Department of Microbiology and Natural Products Research, Mead Johnson Research Center, Mead Johnson & Co., Evansville, Indiana.
Appl Microbiol. 1966 Nov;14(6):953-6. doi: 10.1128/am.14.6.953-956.1966.
Eleven antifungal antibiotics, representing three broad macrolide classes, were studied in Candida albicans for their effect on growth and on the fate of intracellular K. Marked differences were observed among these antibiotics between their growth-inhibitory activities and their adverse effects on the integrity of the cellular membrane as evidenced by loss of K. Antibiotics most active in inhibiting growth of C. albicans were amphotericin B, trichomycin, candidin, candicidin (all heptaenes), and nystatin (a tetraene). In addition to those antibiotics, filipin and fungichromin also caused rapid leakage of K from yeast cells. Interestingly, fungichromin was the least active of the 11 antibiotics in inhibiting growth. Concentrations of rimocidin 10 times as great as those required for growth inhibition caused only a slight loss in intracellular K after 60 min.
研究了代表三大类大环内酯的11种抗真菌抗生素对白色念珠菌生长以及细胞内钾离子命运的影响。这些抗生素在抑制生长活性和对细胞膜完整性的不利影响（以钾离子流失为证据）之间存在显著差异。在抑制白色念珠菌生长方面最具活性的抗生素是两性霉素B、曲古霉素、杀假丝菌素、杀念珠菌素（均为七烯类）和制霉菌素（一种四烯类）。除了这些抗生素外，菲律宾菌素和真菌色素也会导致酵母细胞中的钾离子快速泄漏。有趣的是，真菌色素是11种抗生素中抑制生长活性最低的。龟裂杀菌素的浓度比抑制生长所需浓度高10倍，60分钟后细胞内钾离子仅轻微流失。
