Altern Ther Health Med. 2022 May;28(4):55-59.
Objectives • This study aimed to assess the diagnostic value of serum brain natriuretic peptide (BNP), cathepsin S (Cat S), serum soluble ST2 receptor (sST2), platelet reactive protein-1 (TSP-1) and interleukin-11 (IL-11) in patients with chronic heart failure (CHF).
Materials and Methods • A total of 112 patients admitted to in our hospital with HF were enrolled as the HF group and 120 healthy people undergoing physical examination were assigned to the control group. The serum levels of Cat S, TSP-1, IL-11, sST2 and BNP were measured and compared in the subgroups categorized according to New York Heart Association (NYHA) Functional Classification. Pearson correlation was applied to analyze the correlation between serum Cat S, TSP-1, IL-11, sST2 and BNP and NYHA functional class. Moreover, multivariate logistic regression was used to analyze the HF influencing factors.
Results • No correlation was found between the 2 groups in terms of general information, such as age, gender, body mass index (BMI), systolic blood pressure, diastolic blood pressure, smoking and heart rate (P > .05). The left ventricular ejection fraction (LVEF) in the HF group was lower than in the control group, while the level of LV end diastolic dimension (LVEDD) and left ventricular end diastolic volume (LVEDV) was significantly higher (P < .05). The levels of Cat S, TSP-1, sST2, IL-11 and BNP in the HF group were higher than in the control group (P < .05). The levels of Cat S, TSP-1, sST2, IL-11 and BNP in the grade IV group were higher than those in the grade II and III groups (P < .05). Serum Cat S, TSP-1, IL-11, sST2 and BNP levels were positively correlated with NYHA functional class (R = 0.568, 0.409, 0.472, 0.547, 0.632, respectively) (P < .001). Multivariate logistic regression analysis demonstrated that LVEF, LVEDD, LVEDV, Cat S, TSP-1, IL-11, sST2 and BNP were independent markers of CHF.
Conclusion • Abnormal Cat S, TSP-1, IL-11, sST2 and BNP levels were found in patients with CHF, and were highly associated with the cardiac function grades of CHF. Therefore, serum Cat S, TSP-1, IL-11, sST2 and BNP levels can serve as independent markers for CHF.
目的 本研究旨在评估血清脑钠肽（BNP）、组织蛋白酶 S（Cat S）、血清可溶性 ST2 受体（sST2）、血小板反应蛋白-1（TSP-1）和白细胞介素-11（IL-11）在慢性心力衰竭（CHF）患者中的诊断价值。
材料和方法 选取我院收治的 112 例 HF 患者为 HF 组，选择同期 120 例健康体检者为对照组。比较两组患者根据纽约心脏协会（NYHA）功能分级的亚组的 Cat S、TSP-1、IL-11、sST2 和 BNP 血清水平。采用 Pearson 相关分析血清 Cat S、TSP-1、IL-11、sST2 和 BNP 与 NYHA 功能分级的相关性。此外，采用多元逻辑回归分析 HF 的影响因素。
结果 两组患者的一般资料如年龄、性别、体重指数（BMI）、收缩压、舒张压、吸烟和心率比较，差异无统计学意义（P＞0.05）。HF 组的左心室射血分数（LVEF）低于对照组，而左心室舒张末期内径（LVEDD）和左心室舒张末期容积（LVEDV）明显高于对照组（P＜0.05）。HF 组的 Cat S、TSP-1、sST2、IL-11 和 BNP 水平均高于对照组（P＜0.05）。IV 级组的 Cat S、TSP-1、sST2、IL-11 和 BNP 水平均高于 II 级和 III 级组（P＜0.05）。血清 Cat S、TSP-1、IL-11、sST2 和 BNP 水平与 NYHA 功能分级呈正相关（R=0.568、0.409、0.472、0.547、0.632，P＜0.001）。多元逻辑回归分析表明，LVEF、LVEDD、LVEDV、Cat S、TSP-1、IL-11、sST2 和 BNP 是 CHF 的独立标志物。
结论 心力衰竭患者 Cat S、TSP-1、IL-11、sST2 和 BNP 水平异常，与心力衰竭的心脏功能分级高度相关。因此，血清 Cat S、TSP-1、IL-11、sST2 和 BNP 水平可作为心力衰竭的独立标志物。
