只收固体废物！
Only solid waste, please!
作者信息
Dormann Dorothee, Behrends Christian
机构信息
Johannes Gutenberg University (JGU) Mainz, Faculty of Biology, Institute of Molecular Physiology, Mainz, Germany; Institute of Molecular Biology (IMB) Mainz, Mainz, Germany.
Munich Cluster for Systems Neurology (SyNergy), Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany.
出版信息
Mol Cell. 2022 Apr 21;82(8):1408-1410. doi: 10.1016/j.molcel.2022.04.003.
To elucidate the mechanism driving selective autophagy of protein aggregates, or "aggrephagy," Ma et al. (2022) identify chaperonin TRiC subunit CCT2 as a receptor that specifically promotes the clearance of solid aggregates, but not liquid-like condensates, in a ubiquitin-independent manner.
为了阐明驱动蛋白质聚集体选择性自噬（即“聚集体自噬”）的机制，Ma等人（2022年）确定伴侣蛋白TRiC亚基CCT2作为一种受体，它以不依赖泛素的方式特异性促进固体聚集体而非类液体凝聚物的清除。
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