功能失调性子宫出血来救援了。

DUB to the rescue.

作者信息

Teh Wei Pin, Zhu He, Marto Jarrod A, Buhrlage Sara J

机构信息

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

出版信息

Mol Cell. 2022 Apr 21;82(8):1411-1413. doi: 10.1016/j.molcel.2022.03.039.

DOI:10.1016/j.molcel.2022.03.039

PMID:35452613

Abstract

Henning et al. (2022) report development of a novel class of agents, bivalent deubiquitinase (DUB)-targeting chimeras (DUBTACs), that can selectively stabilize protein targets. These findings encourage further pursuit of targeted protein stabilization as a new paradigm in chemical biology and drug discovery.

摘要

亨宁等人（2022年）报告了一类新型药物的研发情况，即双价去泛素化酶（DUB）靶向嵌合体（DUBTACs），这类药物能够选择性地稳定蛋白质靶点。这些发现促使人们进一步探索将靶向蛋白质稳定化作为化学生物学和药物发现中的一种新范式。