未服药的双相情感障碍和重度抑郁症的区域性脑血流和功能连接的共同和特有特征。
Shared and specific characteristics of regional cerebral blood flow and functional connectivity in unmedicated bipolar and major depressive disorders.
机构信息
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China.
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
出版信息
J Affect Disord. 2022 Jul 15;309:77-84. doi: 10.1016/j.jad.2022.04.099. Epub 2022 Apr 20.
BACKGROUND
Identifying brain similarities and differences between bipolar disorder (BD) and major depressive disorder (MDD) can help us better understand their pathophysiological mechanisms and develop more effective treatments. However, the features of whole-brain regional cerebral blood flow (CBF) and intrinsic functional connectivity (FC) underlying BD and MDD have not been directly compared.
METHODS
Eighty-eight unmedicated BD II depression patients, 95 unmedicated MDD patients, and 96 healthy controls (HCs) underwent three-dimensional arterial spin labeling (3D ASL) and resting-state functional MRI (rs-fMRI). The functional properties of whole brain CBF and seed-based resting-state FC further performed based on those regions with changed CBF were analyzed between the three groups.
RESULTS
The patients with BD and MDD showed commonly increased CBF in the left posterior lobe of the cerebellum and the left middle temporal gyrus (MTG) compared with HCs. The CBF of the left MTG was positively associated with 24-items Hamilton Depression Rating Scale scores in MDD patients. Decreased FC between the left posterior lobe of the cerebellum and the left inferior frontal gyrus (IFG) was observed only in patients with BD compared with HCs.
CONCLUSION
Patients with BD and those with MDD shared common features of CBF in the posterior lobe of the cerebellum and the MTG. The altered posterior lobe of the cerebellum-IFG FC can be considered as a potential biomarker for the differentiation of patients with BD from those with MDD.
背景
比较双相情感障碍（BD）和重度抑郁症（MDD）患者大脑的相似和差异，有助于我们更好地理解其病理生理学机制，并开发更有效的治疗方法。然而，BD 和 MDD 全脑区域脑血流（CBF）和固有功能连接（FC）的特征尚未直接比较。
方法
88 名未经治疗的 BD II 抑郁患者、95 名未经治疗的 MDD 患者和 96 名健康对照者（HCs）接受了三维动脉自旋标记（3D ASL）和静息态功能磁共振成像（rs-fMRI）检查。在三组之间，基于那些 CBF 改变的区域，进一步分析了全脑 CBF 和基于种子的静息态 FC 的功能特性。
结果
BD 和 MDD 患者与 HCs 相比，左小脑后叶和左颞中回（MTG）的 CBF 普遍增加。MDD 患者左 MTG 的 CBF 与 24 项汉密尔顿抑郁量表评分呈正相关。与 HCs 相比，仅在 BD 患者中观察到左小脑后叶与左额下回（IFG）之间 FC 的降低。
结论
BD 和 MDD 患者在小脑后叶和 MTG 存在共同的 CBF 特征。小脑后叶-IFG FC 的改变可作为 BD 与 MDD 患者区分的潜在生物标志物。
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