[血清素与吖啶橙染料对DNA的竞争性相互作用]
[Competitive interaction of serotonin and the dye acridine orange with DNA].
作者信息
Strakhovskaia M G, Kirpichnikova N A, Fraĭkin G Ia
出版信息
Nauchnye Doki Vyss Shkoly Biol Nauki. 1986(11):33-6.
The interaction of serotonin and acridine orange dye with DNA isolated from bacterium Escherichia coli and the yeast Candida utilis has been analysed by spectrofluorimetric method. Using data on competitive binding to DNA of serotonin and acridine orange, known as DNA intercalator, a conclusion concerning the formation of intercalated complex between serotonin and DNA has been made. It is shown that for yeast DNA the constant of intercalated binding of serotonin is 3,5-fold smaller than for the bacterial one.
已通过荧光分光光度法分析了血清素和吖啶橙染料与从大肠杆菌和产朊假丝酵母中分离出的DNA的相互作用。利用血清素和作为DNA嵌入剂的吖啶橙与DNA竞争性结合的数据，得出了关于血清素与DNA之间形成嵌入复合物的结论。结果表明，对于酵母DNA，血清素的嵌入结合常数比细菌DNA的嵌入结合常数小3.5倍。
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